Department of Plant Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Department of Plant Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Biomed Pharmacother. 2019 Jan;109:1381-1393. doi: 10.1016/j.biopha.2018.10.107. Epub 2018 Nov 12.
Skin cancer is a life threatening disease and their prevalence and risk has been increasing over the past three decades causing significant loss to human health worldwide. Mostly skin cancer has developed resistance against chemotherapy and radiotherapy. Therefore, development of novel, cost effective and efficient treatment methods are needed. Phytochemicals extracted from medicinal plants and dietary sources are often biologically active and has attracted the attention of researchers and pharmaceutical industries around the world. Many in vitro and in vivo studies of these bioactive compounds have shown potential antioxidant, anti-proliferative, anti-inflammatory and anti-angiogenic effects in the fight against skin cancer. These phytochemicals also regulate several other molecular processes such as angiogenesis, metastasis and cell cycle to combat skin cancer. The present review provides perspectives on the key phytochemicals, their therapeutic potentials, bioavailability and molecular mechanism of action in the cancer therapeutics. Current challenges and future directions for research are also critically discussed.
皮肤癌是一种危及生命的疾病，在过去三十年中，其发病率和风险一直在增加，给全球人类健康造成了重大损失。大多数皮肤癌已经对化疗和放疗产生了耐药性。因此，需要开发新型、经济高效的治疗方法。从药用植物和饮食来源提取的植物化学物质通常具有生物活性，引起了世界各地研究人员和制药行业的关注。对这些生物活性化合物的许多体外和体内研究表明，它们在对抗皮肤癌方面具有潜在的抗氧化、抗增殖、抗炎和抗血管生成作用。这些植物化学物质还调节血管生成、转移和细胞周期等其他几个分子过程，以对抗皮肤癌。本综述提供了关于关键植物化学物质的观点，包括它们在癌症治疗中的治疗潜力、生物利用度和作用机制。还批判性地讨论了当前的挑战和未来的研究方向。
