A Sumithra, Kani Vallal, Vasudevan Sudha, Esakki Muthuvel
Department of Pathology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus. 2024 Sep 2;16(9):e68452. doi: 10.7759/cureus.68452. eCollection 2024 Sep.
Dedifferentiated chondrosarcomas (DDCS) are highly aggressive tumors with poor outcomes. Chondrosarcoma (CS) can be categorized based on localization (periosteal, central, and peripheral) or histology, with conventional CS being the most common subtype. However, rarer histological types, such as clear-cell CS, DDCS, and mesenchymal CS, also exist. We present a unique case of DDCS in a 28-year-old male who presented with swelling on the proximal phalanx of the fourth finger. Radiographs showed sclerotic margins and a central diaphyseal lytic lesion. Immunohistochemical analysis using S-100 and Ki67 markers confirmed the diagnosis of DDCS. Treatment involved a multidisciplinary approach, including surgical resection, adjuvant chemotherapy, and radiation therapy. This case underscores the importance of early identification of DDCS and the need for tailored management strategies to address its specific characteristics.
去分化软骨肉瘤（DDCS）是一种侵袭性很强、预后很差的肿瘤。软骨肉瘤（CS）可根据部位（骨膜性、中央性和周围性）或组织学进行分类，其中传统型CS是最常见的亚型。然而，也存在一些罕见的组织学类型，如透明细胞CS、DDCS和间叶性CS。我们报告了一例28岁男性的DDCS罕见病例，该患者表现为右手第四指近节指骨肿胀。X线片显示硬化边缘和中央骨干溶骨性病变。使用S-100和Ki67标记物的免疫组织化学分析确诊为DDCS。治疗采用多学科方法，包括手术切除、辅助化疗和放射治疗。该病例强调了早期识别DDCS的重要性以及针对其特殊特征制定个性化管理策略的必要性。
