Department of Oncology, Zhejiang University School of Medicine Women's Hospital, Hangzhou, Zhejiang Province, China.
Department of Pathology, Zhejiang University School of Medicine Women's Hospital, Hangzhou, Zhejiang Province, China.
J Int Med Res. 2024 Oct;52(10):3000605241283632. doi: 10.1177/03000605241283632.
The morphology of the choriocarcinomatous variant of cervical squamous cell carcinoma (SCC) suggests an undifferentiated aggressive biological behaviour and a poor outcome, for which standard treatment has not been established. In addition, cases are rarely reported, with only five cases of patients with cervical carcinoma with choriocarcinoma reported previously in the literature. This current case report describes in detail a patient who was diagnosed with cervical SCC mixed with choriocarcinomatous differentiation. The case report includes details of the diagnosis, pathology, short tandem repeat genotyping, treatment and follow-up of this patient. As there is no standard treatment for this variant, the patient underwent surgery followed by radiotherapy. Unfortunately, 4 months after therapy discontinuation, radiological evaluation and laboratory tests documented a recurrence of the disease and the patient died. This report also systematically reviews the literature on cervical cancer associated with choriocarcinomatous differentiation and the five previous cases. It provides the most up-to-date summary of this disease, including its clinical manifestations, histopathology, diagnosis, treatment and prognosis.
宫颈鳞状细胞癌（SCC）绒毛膜癌变异型的形态学提示其具有未分化的侵袭性生物学行为和不良预后，目前尚未确立标准治疗方法。此外，此类病例罕见，文献中仅报道了五例宫颈腺癌合并绒毛膜癌分化的病例。本病例报告详细描述了 1 例宫颈 SCC 合并绒毛膜癌分化的患者。该病例报告包括该患者的诊断、病理学、短串联重复基因分型、治疗和随访的详细信息。由于这种变异型没有标准的治疗方法，该患者接受了手术加放疗。不幸的是，在停止治疗 4 个月后，影像学评估和实验室检查证实疾病复发，患者死亡。本报告还系统地回顾了与绒毛膜癌分化相关的宫颈癌的文献以及之前的五例病例。它提供了对这种疾病的最新总结，包括其临床表现、组织病理学、诊断、治疗和预后。
