Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Africa Academy for Public Health, Dar es Salaam, Tanzania.
J Int Assoc Provid AIDS Care. 2024 Jan-Dec;23:23259582241281010. doi: 10.1177/23259582241281010.
Antiretroviral therapy (ART) has improved the survival of people living with HIV (PLHIV) but this success has been accompanied by an increase in noncommunicable diseases. We conducted a prospective cohort study of 4000 adult PLHIV who were initiating ART in Dar es Salaam, Tanzania, to assess weight gain during the first year of treatment and associated sociodemographic and clinical factors. Anthropometric data were collected at ART initiation and monthly follow-up visits. The mean weight gain during the first year of treatment was 2.6 ± 0.3 kg, and the prevalence of overweight or obesity increased from 26.3% at baseline to 40.7%. Female sex, greater household wealth, lower CD4-T-cell counts, higher WHO HIV disease stage, and pulmonary tuberculosis were associated with a greater increase in body mass index ( < .05). Weight gain following ART initiation was common but was greater among females and PLHIV with advanced HIV or comorbidities.
抗逆转录病毒疗法 (ART) 提高了艾滋病毒感染者 (PLHIV) 的生存率，但这一成功伴随着非传染性疾病的增加。我们对坦桑尼亚达累斯萨拉姆的 4000 名开始接受 ART 治疗的成年 PLHIV 进行了一项前瞻性队列研究，以评估治疗的第一年体重增加情况以及相关的社会人口学和临床因素。在开始接受 ART 治疗时和每月的随访访问中收集了人体测量数据。治疗的第一年体重平均增加了 2.6 ± 0.3kg，超重或肥胖的患病率从基线时的 26.3%增加到 40.7%。女性、家庭财富更多、CD4-T 细胞计数更低、更高的世界卫生组织 HIV 疾病阶段和肺结核与体重指数的更大增加相关（<0.05）。ART 治疗开始后体重增加很常见，但在女性和 HIV 更为晚期或合并症的 PLHIV 中更为常见。
