Kintu Alexander, Liu Enju, Hertzmark Ellen, Spiegelman Donna, Zack Rachel Margaret, Muya Aisa, Sando David, Bärnighausen Till, Fawzi Wafaie
1 Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
2 Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
J Int Assoc Provid AIDS Care. 2018 Jan-Dec;17:2325958218759759. doi: 10.1177/2325958218759759.
To describe the incidence of and risk factors for overweight and obesity following antiretroviral therapy (ART) initiation.
We used Cox proportional hazards models to investigate risk factors for incident overweight and obesity in 79 074 individuals aged 15 years or older who initiated ART in Dar es Salaam, Tanzania.
Twenty-five percent of the patients became overweight and 10% became obese. The incidence rate of obesity was 3.2 per 100 person-years (95% confidence interval [CI]: 3.1-3.3) in patients who were of normal weight before starting ART and 22.6 per 100 person-years (95% CI: 21.9-23.3) in those who were overweight. Lower CD4 count was associated with a higher risk of overweight and obesity ( P value for trend < .0001).
There is a high burden of overweight and obesity after starting ART, leading to proportions of these 2 conditions that are similar to those in the general population.
描述开始抗逆转录病毒治疗（ART）后超重和肥胖的发生率及危险因素。
我们使用Cox比例风险模型，调查了坦桑尼亚达累斯萨拉姆79074名15岁及以上开始接受ART治疗的个体发生超重和肥胖的危险因素。
25%的患者超重，10%的患者肥胖。开始ART治疗前体重正常的患者肥胖发生率为每100人年3.2例（95%置信区间[CI]：3.1 - 3.3），超重患者为每100人年22.6例（95%CI：21.9 - 23.3）。较低的CD4细胞计数与超重和肥胖风险较高相关（趋势P值<0.0001）。
开始ART治疗后超重和肥胖负担较重，这两种情况的比例与普通人群相似。
