Enhanced Sonodynamic Therapy for Deep Tumors Using a Self-Assembled Organoplatinum(II) Sonosensitizer.

Despite the promising advances in photodynamic therapy (PDT), it remains challenging to target and treat deep-seated solid tumors effectively. Herein, we developed an organoplatinum(II) complex () with self-assembly properties for sonodynamic therapy (SDT). forms a nanofiber network structure through Pt-Pt and π-π stacking interactions. Notably, under ultrasound (US), demonstrates unique self-assembly-induced singlet oxygen (O) generation due to a significantly enhanced singlet-triplet intersystem crossing (ISC). This generation of O occurs exclusively in the self-assembled state of . Additionally, exhibits sono-cytotoxicity against cancer cells by impairing mitochondrial membrane potential (MMP), inhibiting glucose uptake, and aerobic glycolysis. Furthermore, US-activated significantly inhibits deep solid tumors in mice, achieving remarkable therapeutic efficacy even at penetration depths greater than 10 cm. This study highlights the potential of self-assembled metal complexes to enhance the efficacy of SDT for treating deep tumors.