一种高效的钌（II）声敏剂和声催化剂，用于体内声疗。
A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy.
机构信息
College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, P. R. China.
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, P. R. China.
出版信息
Nat Commun. 2021 Aug 18;12(1):5001. doi: 10.1038/s41467-021-25303-1.
As a basic structure of most polypyridinal metal complexes, [Ru(bpy)], has the advantages of simple structure, facile synthesis and high yield, which has great potential for scientific research and application. However, sonodynamic therapy (SDT) performance of [Ru(bpy)] has not been investigated so far. SDT can overcome the tissue-penetration and phototoxicity problems compared to photodynamic therapy. Here, we report that [Ru(bpy)] is a highly potent sonosensitizer and sonocatalyst for sonotherapy in vitro and in vivo. [Ru(bpy)] can produce singlet oxygen (O) and sono-oxidize endogenous 1,4-dihydronicotinamide adenine dinucleotide (NADH) under ultrasound (US) stimulation in cancer cells. Furthermore, [Ru(bpy)] enables effective destruction of mice tumors, and the therapeutic effect can reach deep tissues over 10 cm under US irradiation. This work paves a way for polypyridinal metal complexes to be applied to the noninvasive precise sonotherapy of cancer.
作为大多数多吡啶金属配合物的基本结构，[Ru(bpy)]具有结构简单、合成容易、产率高的优点，具有很大的科研和应用潜力。然而，[Ru(bpy)]的声动力学治疗（SDT）性能迄今尚未得到研究。与光动力疗法相比，声动力学疗法可以克服组织穿透和光毒性问题。在这里，我们报告[Ru(bpy)]是一种高效的声敏剂和声催化剂，可用于体外和体内的声疗。[Ru(bpy)]可以在超声（US）刺激下在癌细胞中产生单线态氧（O）并声氧化内源性 1,4-二氢烟酰胺腺嘌呤二核苷酸（NADH）。此外，[Ru(bpy)]能够有效破坏小鼠肿瘤，并且在超声照射下，治疗效果可以达到 10 cm 以上的深部组织。这项工作为多吡啶金属配合物应用于癌症的无创精确声疗铺平了道路。
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