Xie Dan-Dan, Li Xue-Lian, Zeng Li-Zhen, Ren Xiaoxia, Zhang Dan, Yang Rong, Gao Feng
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy, Yunnan University, Kunming, 650500, P. R. China.
Animal Research and Resource Center, School of Life Sciences, Yunnan University, Kunming, 650500, P. R. China.
Chembiochem. 2025 Feb 1;26(3):e202400801. doi: 10.1002/cbic.202400801. Epub 2024 Nov 26.
Six polypyridyl Ru(II) complexes were designed for single-molecule photodynamic and sonodynamic therapy (PDT/SDT) synergistic multimodal anticancer toward cisplatin-resistant NSCLC. They demonstrated lowest 3ES with distinct intraligand transition nature, which is beneficial for singlet oxygen generation. Remarkable quantum yields of both singlet oxygen and superoxide anion under either 808 nm laser irradiation or ultrasonic treatment and could induce apoptosis and ferroptosis of A549R cells. Cytotoxicity experiments clearly demonstrated a synergistic effect between PDT and SDT. The relationship between the structures of these complexes and their cellular biological mechanisms has been explored in detail. Using a single-molecule sensitizer to achieve synergistic PDT/SDT may provide valuable insights for the treatment of drug-resistant tumors that located deeply and in hypoxic microenvironment.
设计了六种聚吡啶钌（II）配合物，用于对顺铂耐药的非小细胞肺癌进行单分子光动力和超声动力疗法（PDT/SDT）协同多模态抗癌。它们表现出最低的三重态激发态，具有独特的配体内跃迁性质，这有利于单线态氧的产生。在808 nm激光照射或超声处理下，单线态氧和超氧阴离子均具有显著的量子产率，并且可以诱导A549R细胞凋亡和铁死亡。细胞毒性实验清楚地证明了PDT和SDT之间的协同作用。已详细探索了这些配合物的结构与其细胞生物学机制之间的关系。使用单分子敏化剂实现协同PDT/SDT可能为治疗深部和低氧微环境中的耐药肿瘤提供有价值的见解。
