Adu Mozili, Qiu Yongwei, Ma Qinge, Zhong Guoyue, Guo Jia-Zeng, Wei Rongrui
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine & Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
College of Jewelry and Jade Carvin, Nanyang Normal University, Nanyang 473061, China.
Comb Chem High Throughput Screen. 2024 Oct 2. doi: 10.2174/0113862073321827240918040737.
RA is a recurrent autoimmune disease that has significant adverse effects on the physical and mental health of patients. Traditional Chinese medicine has shown significant advantages in the prevention and treatment of RA. Numerous clinical and experimental studies have confirmed that traditional Chinese medicine components have clear therapeutic effects and minimal adverse reactions in treating RA. The research on traditional Chinese medicine for the prevention and treatment of RA has become a hot topic in the field of autoimmune diseases.
The related references about the mechanisms and Q-markers of anti-RA of traditional Chinese medicine in this review were collected from Willy, SpringLink, Web of Science, Elsevier, PubMed, SciFinder, Scopus, ACS publications, Baidu Scholar, Google Scholar, and CNKI.
The traditional Chinese medicine components such as terpenoids, flavonoids, and alkaloids have significant anti-RA effects, and their mechanisms are mainly to inhibit NF-κB signaling pathway, inhibit the proliferation of RA fibroblasts like synovial cells, and regulate Th1/Th2 cell balance, and so on. Predicting and studying the Q-markers of traditional Chinese medicine anti-RA by plant phylogeny and chemical componentss, traditional medicinal properties, pharmacokinetics, component measurability, correlation between composition and efficacy, and gut microbiota will provide scientific foundations for the research and further development of anti-RA traditional Chinese medicine.
The active components of traditional Chinese medicine exhibited the characteristic of multiple mechanisms in the treatment of RA, such as terpenoids had anti-angiogenesis effects, flavonoids had anti-inflammatory and cartilage protective effects, and alkaloids had antiinflammatory and analgesic effects. The proposal of Q-markers for anti-RA provided new research ideas for promoting the development of new drugs for anti-RA and ensuring the safety and effectiveness of clinical medications.
类风湿关节炎（RA）是一种复发性自身免疫性疾病，对患者的身心健康有显著不良影响。中医在RA的防治方面已显示出显著优势。众多临床和实验研究证实，中药成分在治疗RA方面具有明确的治疗效果且不良反应极小。中药防治RA的研究已成为自身免疫性疾病领域的热点话题。
本综述中关于中药抗RA机制及Q-标志物的相关参考文献收集自威利、SpringerLink、科学网、爱思唯尔、PubMed、SciFinder、Scopus、美国化学会出版物、百度学术、谷歌学术和中国知网。
萜类、黄酮类和生物碱类等中药成分具有显著的抗RA作用，其作用机制主要是抑制核因子κB信号通路、抑制类风湿关节炎成纤维样滑膜细胞增殖以及调节Th1/Th2细胞平衡等。通过植物系统发育与化学成分、传统药性、药代动力学、成分可测性、成分与药效的相关性以及肠道菌群等对中药抗RA的Q-标志物进行预测和研究，将为抗RA中药的研究及进一步开发提供科学依据。
中药活性成分在治疗RA时呈现多机制特点，如萜类具有抗血管生成作用，黄酮类具有抗炎和软骨保护作用，生物碱类具有抗炎和镇痛作用。抗RA的Q-标志物的提出为推动抗RA新药研发及确保临床用药的安全性和有效性提供了新的研究思路。
