姜衍生的纳米囊泡通过抑制 Nrf2 通路的氧化应激来减轻骨关节炎的进展。
Ginger-derived nanovesicles attenuate osteoarthritis progression by inhibiting oxidative stress via the Nrf2 pathway.
机构信息
Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Department of Burns & Plastic Surgery, The Affiliated Hospital of Jiangnan University, Wuxi, 214041, China.
出版信息
Nanomedicine (Lond). 2024;19(28):2357-2373. doi: 10.1080/17435889.2024.2403324. Epub 2024 Oct 3.
Osteoarthritis (OA) is a common degenerative joint disease. Previous studies demonstrated ginger-derived exosome-like nanovesicles (GDN) showed therapeutic effects in degenerative diseases. However, it remains unknown whether GDN could alleviate OA progression. In this study, GDN were obtained and characterized. Then we evaluated the effects of GDN in tert-butyl hydroperoxide (TBHP)-induced chondrocytes, posttraumatic OA rat model and cultured human OA cartilage explants. We demonstrated GDN promoted cartilage anabolism and alleviated oxidative stress in TBHP-induced chondrocytes and OA rat. Our results also showed GDN exhibited protective effects in cultured cartilage explants. Furthermore, we verified the Nrf2 pathway was associated with protective effects of GDN. Altogether, our findings demonstrated GDN hold great potential for OA treatment.
骨关节炎（OA）是一种常见的退行性关节疾病。先前的研究表明，姜衍生的外泌体样纳米囊泡（GDN）在退行性疾病中显示出治疗效果。然而，目前尚不清楚 GDN 是否可以缓解 OA 的进展。在这项研究中，我们获得并表征了 GDN。然后，我们评估了 GDN 在叔丁基过氧化物（TBHP）诱导的软骨细胞、创伤后 OA 大鼠模型和培养的人 OA 软骨外植体中的作用。我们证明 GDN 促进软骨合成代谢并减轻 TBHP 诱导的软骨细胞和 OA 大鼠中的氧化应激。我们的结果还表明 GDN 在培养的软骨外植体中表现出保护作用。此外，我们验证了 Nrf2 途径与 GDN 的保护作用有关。总之，我们的研究结果表明 GDN 在 OA 治疗方面具有很大的潜力。
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