Di Raimo Rossella, Mizzoni Davide, Spada Massimo, Dolo Vincenza, Fais Stefano, Logozzi Mariantonia
Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.
ExoLab Italia, Tecnopolo d'Abruzzo, 67100 L'Aquila, Italy.
Antioxidants (Basel). 2023 May 29;12(6):1169. doi: 10.3390/antiox12061169.
Plant-derived exosomes (PDEs) are receiving much attention as a natural source of antioxidants. Previous research has shown that PDEs contain a series of bioactives and that their content varies depending on the fruit or vegetable source. It has also been shown that fruits and vegetables derived from organic agriculture produce more exosomes, are safer, free of toxic substances, and contain more bioactives. The aim of this study was to investigate the ability of orally administered mixes of PDE (Exocomplex) to restore the physiological conditions of mice treated for two weeks with hydrogen peroxide (HO), compared with mice left untreated after the period of HO administration and mice that received only water during the experimental period. The results showed that Exocomplex had a high antioxidant capacity and contained a series of bioactives, including Catalase, Glutathione (GSH), Superoxide Dismutase (SOD), Ascorbic Acid, Melatonin, Phenolic compounds, and ATP. The oral administration of Exocomplex to the HO-treated mice re-established redox balance with reduced serum levels of both reactive oxygen species (ROS) and malondialdehyde (MDA), but also a general recovery of the homeostatic condition at the organ level, supporting the future use of PDE for health care.
植物源外泌体（PDEs）作为抗氧化剂的天然来源正受到广泛关注。先前的研究表明，PDEs含有一系列生物活性物质，其含量因水果或蔬菜来源而异。研究还表明，有机农业生产的水果和蔬菜能产生更多外泌体，更安全，不含有毒物质，且含有更多生物活性物质。本研究的目的是调查口服PDE混合物（Exocomplex）恢复用过氧化氢（HO）处理两周的小鼠生理状况的能力，并将其与HO给药期后未处理的小鼠以及实验期间仅接受水的小鼠进行比较。结果表明，Exocomplex具有高抗氧化能力，含有一系列生物活性物质，包括过氧化氢酶、谷胱甘肽（GSH）、超氧化物歧化酶（SOD）、抗坏血酸、褪黑素、酚类化合物和ATP。给HO处理的小鼠口服Exocomplex可恢复氧化还原平衡，降低血清中活性氧（ROS）和丙二醛（MDA）的水平，同时使器官水平的稳态状况总体恢复，这为PDE在医疗保健中的未来应用提供了支持。
