乳糜泻和非乳糜泻肠病。
Celiac disease and nonceliac enteropathies.
机构信息
Division of Digestive and Liver Diseases, Columbia University Irving Medical Center.
The Celiac Disease Center at Columbia University, New York, New York, USA.
出版信息
Curr Opin Gastroenterol. 2024 Nov 1;40(6):464-469. doi: 10.1097/MOG.0000000000001048. Epub 2024 Jun 14.
PURPOSE OF REVIEW
This review highlights recent research in the field of celiac disease.
RECENT FINDINGS
Epidemiological studies continue to identify celiac disease-associated diseases such as inflammatory arthritis, irritable bowel syndrome, and cardiovascular disease. Recently published consensus guidelines provide recommendations for the long-term management and monitoring of patients with celiac disease. There are multiple pharmaceutical therapies for celiac disease under investigation, and recent phase I and phase II trials are reviewed here. Finally, a recent trial of patients with nonceliac gluten sensitivity demonstrates a significant nocebo effect in this condition.
SUMMARY
Recent advances in celiac disease include the development of new clinical guidelines as well as promising new therapeutics. Continued high-quality research is needed to improve the outcomes of patients with celiac disease and nonceliac enteropathies.
目的综述
本文重点介绍了乳糜泻领域的最新研究进展。
最近的发现
流行病学研究继续发现乳糜泻相关疾病，如炎性关节炎、肠易激综合征和心血管疾病。最近发表的共识指南为乳糜泻患者的长期管理和监测提供了建议。目前正在研究多种治疗乳糜泻的药物，本文对最近的 I 期和 II 期临床试验进行了综述。最后，一项非乳糜泻性麸质敏感性患者的临床试验表明，在这种情况下存在显著的反安慰剂效应。
总结
乳糜泻的最新进展包括新临床指南的制定以及有前途的新疗法。需要进行高质量的研究，以改善乳糜泻和非乳糜泻肠病患者的预后。
Zotero 插件