Didona Dario, Maglie Roberto, Solimani Farzan
Department of Dermatology, Rare Skin Diseases Center, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy.
Department of Health Sciences, Section of Dermatology, University of Florence, Florence, Italy.
J Dtsch Dermatol Ges. 2025 Jul;23(7):857-867. doi: 10.1111/ddg.15704. Epub 2025 Jul 9.
Gluten-related disorders (GRDs) encompass a spectrum of clinical manifestations triggered by gluten ingestion in genetically susceptible individuals. These disorders include celiac disease (CD) and non-celiac gluten sensitivity (NCGS) and present with both intestinal and extraintestinal symptoms, including skin manifestations. Besides the well-known association between CD and dermatitis herpetiformis, considered as the cutaneous manifestation of CD, other dermatoses have been associated to GRDs. In this paper, we provide a concise overview of the clinical appearance, diagnosis and therapeutic management of GRDs, a tool which we hope will facilitate clinicians when faced with this challenging group of diseases.
麸质相关疾病(GRDs)包括一系列由基因易感个体摄入麸质引发的临床表现。这些疾病包括乳糜泻(CD)和非乳糜泻麸质敏感(NCGS),并伴有肠道和肠道外症状,包括皮肤表现。除了众所周知的CD与疱疹样皮炎之间的关联(疱疹样皮炎被认为是CD的皮肤表现)外,其他皮肤病也与GRDs有关。在本文中,我们简要概述了GRDs的临床表现、诊断和治疗管理,希望这一工具能在临床医生面对这一具有挑战性的疾病群体时提供帮助。