一种新型的保护和修复护肤方案显示出改善环境皮肤老化的功效。

A Novel Protection and Repair Skincare Regimen Shows Efficacy for Improving Environmental Skin Aging.

出版信息

J Drugs Dermatol. 2024 Oct 1;23(10):866-872. doi: 10.36849/JDD.2024.8274.

DOI:10.36849/JDD.2024.8274

Abstract

BACKGROUND

Skin aging is accelerated by environmental exposures including solar radiation and pollutants. Thus, protecting skin from environmental exposure and repairing ensuing damage is essential for keeping skin healthy and appearing youthful.

PURPOSE

To evaluate the clinical benefits of a novel skincare regimen designed to provide comprehensive environmental protection in the daytime and repair environmentally damaged skin at night.

METHODS

Thirty participants, including males and females, with mild-to-moderate extrinsic aging, were enrolled in a 12-week single-site study. Participants used the regimen (The Essential Six, RATIONALE, Victoria, Australia) comprised of 3 products to protect the skin in the morning and 3 products to repair the skin at night. Participants were seen at baseline and evaluated for efficacy and tolerability at weeks 2, 6, and 12. Non-invasive measurements to evaluate hydration, transepidermal water loss, skin tone, and elasticity were conducted.

RESULTS

The dermatologist investigator noted across-the-board improvement in all evaluated parameters, except deep wrinkles. By week 12, there were statistically significant (P<0.001) improvements in radiance (43%), tactile roughness (48%), visual roughness (44%), firmness (32%), clarity/even skin tone (21%), and overall appearance (29%). Fine lines improved 16% at week 12 (P=0.002). Participant self-assessment revealed statistically significant and progressive improvement in all evaluated parameters over time. No tolerability issues were identified by the investigator, while a small number of participants reported mild stinging and some dryness that resolved over time. This was likely due to the high concentration of active ingredients found in this regimen. Corneometry revealed improved skin hydration of 28% as early as week 2.

CONCLUSION

The data presented confirms that this novel protection and repair regimen improves the appearance of environmentally aged skin. J Drugs Dermatol. 2024;23(10):866-872. doi:10.36849/JDD.8274.

摘要

背景

皮肤老化是由环境暴露引起的，包括太阳辐射和污染物。因此，保护皮肤免受环境暴露并修复由此造成的损伤对于保持皮肤健康和年轻外观至关重要。

目的

评估一种新型护肤方案的临床益处，该方案旨在白天提供全面的环境防护，晚上修复受环境损伤的皮肤。

方法

30 名男性和女性参与者，有轻度至中度的外源性衰老，参加了一项为期 12 周的单站点研究。参与者使用该方案（RATIONALE，澳大利亚维多利亚的 The Essential Six），包括 3 种白天保护皮肤的产品和 3 种夜间修复皮肤的产品。在基线和第 2、6 和 12 周评估疗效和耐受性。进行了非侵入性测量，以评估皮肤水分、经表皮水分流失、肤色和弹性。

结果

皮肤科医生调查员注意到所有评估参数均有全面改善，除了深度皱纹。到第 12 周，光泽度（43%）、触感粗糙度（48%）、视觉粗糙度（44%）、紧致度（32%）、清晰度/均匀肤色（21%）和整体外观（29%）均有统计学显著改善（P＜0.001）。第 12 周时，细纹改善了 16%（P=0.002）。参与者自我评估显示，随着时间的推移，所有评估参数均有统计学显著和渐进性改善。调查员未发现任何耐受性问题，尽管少数参与者报告有轻微刺痛和一些干燥，随着时间的推移这些问题得到解决。这可能是由于该方案中含有高浓度的活性成分。皮肤电导率测量显示，早在第 2 周，皮肤水分就改善了 28%。