Koric Alzina, Chang Chun-Pin, Hu Siqi, Snyder John, Deshmukh Vikrant G, Newman Michael G, Date Ankita P, Monroe Marcus M, Hashibe Mia
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, United States; Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, Utah, United States.
Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, Utah, United States.
Oral Oncol. 2024 Dec;159:107062. doi: 10.1016/j.oraloncology.2024.107062. Epub 2024 Oct 2.
The incidence of oropharyngeal cancer continues to rise in the United States, yet studies on the quality of life (QoL) of oropharyngeal cancer patients are limited. The objective of this pilot study was to assess the impact of oral health on the QoL in oropharyngeal cancer survivors.
Oropharyngeal cancer survivors with a confirmed cancer diagnosis from 1996 to 2016 were sampled from the Utah Cancer Registry. The Oral Health Impact Profile-14 (OHIP-14) questionnaire was administrated between January and May of 2019. The impact of oral health on QoL was evaluated using simple linear regression (β-coefficient).
Among the 260 oropharyngeal cancer survivors, the majority were male (84.6 %) and ≥ 60 years of age at the time of cancer diagnosis (74.0 %). The most frequently reported symptoms of OHIP-14 were discomfort while eating any foods (19.2 %) and worsening sense of taste (16.0 %). The overall OHIP-14 mean score was 13.3. Significantly worse OHIP-14 scores were observed for females (β = 12.85, p = 0.01), chemotherapy recipients (β = 6.60, p = 0.02), and past smokers (β = 5.25, p = 0.04). Better OHIP-14 scores (better oral QoL) were observed in patients with distant cancer stage (β = -7.66, p = 0.01), higher income (β = -2.50, p = 0.05), and older age at cancer diagnosis (β = -0.35, p = 0.03).
The oral health-related quality of life scores observed in this pilot study suggest a need for improvement in patient symptom management over time.
在美国，口咽癌的发病率持续上升，但关于口咽癌患者生活质量（QoL）的研究有限。本试点研究的目的是评估口腔健康对口咽癌幸存者生活质量的影响。
从犹他州癌症登记处抽取1996年至2016年确诊患有癌症的口咽癌幸存者。2019年1月至5月期间发放了口腔健康影响程度量表-14（OHIP-14）问卷。使用简单线性回归（β系数）评估口腔健康对生活质量的影响。
在260名头咽癌幸存者中，大多数为男性（84.6%），癌症诊断时年龄≥60岁（74.0%）。OHIP-14最常报告的症状是吃任何食物时不适（19.2%）和味觉恶化（16.0%）。OHIP-14的总体平均得分为13.3。女性（β = 12.85，p = 0.01）、接受化疗者（β = 6.60，p = 0.02）和既往吸烟者（β = 5.25，p = 0.04）的OHIP-14得分明显更差。远处癌症分期患者（β = -7.66，p = 0.01）、收入较高者（β = -2.50，p = 0.05）和癌症诊断时年龄较大者（β = -0.35，p = 0.03）的OHIP-14得分较好（口腔生活质量较好）。
本试点研究中观察到的与口腔健康相关的生活质量得分表明，随着时间的推移，患者症状管理需要改善。
