Scott M T, Neal R A, Woods N C
Trans R Soc Trop Med Hyg. 1985;79(4):451-4. doi: 10.1016/0035-9203(85)90061-6.
Marmosets (Callithrix jacchus) have been immunized with a vaccine comprising a Trypanosoma cruzi 90K cell surface glycoprotein and the adjuvant saponin; a combination previously shown to be protective in mice. Immunization was by two s.c. injections one month apart and non-lethal challenge of homologous Y strain T. cruzi was given one month after the booster immunization. No anti-T. cruzi antibodies were detected after the first immunization but high levels developed after boosting. Immunization caused a significant decrease in the levels of acute phase blood parasitaemia, however, both immunized and control animals remained xenodiagnosis positive 60 weeks after infection. No ECG aberrations, histopathological lesions or anti-tissue antibodies were detected in infected marmosets.
已用一种包含克氏锥虫90K细胞表面糖蛋白和佐剂皂苷的疫苗对狨猴（Callithrix jacchus）进行免疫；先前已证明该组合对小鼠具有保护作用。免疫方式为皮下注射两次，间隔一个月，在加强免疫一个月后对同源Y株克氏锥虫进行非致死性攻击。首次免疫后未检测到抗克氏锥虫抗体，但加强免疫后抗体水平升高。免疫导致急性期血液寄生虫血症水平显著降低，然而，感染60周后，免疫动物和对照动物的异种诊断均呈阳性。在感染的狨猴中未检测到心电图异常、组织病理学病变或抗组织抗体。
