Søndergaard K, Schou G
Virchows Arch A Pathol Anat Histopathol. 1985;408(2-3):249-58. doi: 10.1007/BF00707987.
Therapeutic and clinico-pathological data of 1,469 patients with clinical stage I malignant melanoma of the skin without histological evidence of fibrotic areas of regression were examined by multivariate regression analysis. In accordance with a previous analysis anatomical site of tumour, tumour thickness, level of invasion, mitotic rate, ulceration, lymphocytic reaction, dominant type of invasive tumour cell, and sex were found to act as independent risk factors. The present analysis, furthermore, showed that size of resection margin, diagnostic biopsy, removal of the deep fascia, age at surgery, as well as presence and depth of nevus cells did not influence prognosis when adjusting for the independent risk factors.
对1469例临床I期皮肤恶性黑色素瘤患者的治疗及临床病理数据进行了多因素回归分析，这些患者无纤维化消退区域的组织学证据。与之前的分析一致，发现肿瘤的解剖部位、肿瘤厚度、浸润水平、有丝分裂率、溃疡、淋巴细胞反应、侵袭性肿瘤细胞的主要类型以及性别是独立的危险因素。此外，本分析表明，在调整独立危险因素后，切除边缘大小、诊断性活检、深筋膜切除、手术年龄以及痣细胞的存在和深度并不影响预后。
