Microbiology Department, Institute for Immunology, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Microbiology Department, Institute for Immunology, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Genes Dev. 2024 Oct 16;38(17-20):808-813. doi: 10.1101/gad.352301.124.
The brain's capacity to predict and anticipate changes in internal and external environments is fundamental to initiating efficient adaptive responses, behaviors, and reflexes that minimize disruptions to physiology. In the context of feeding control, the brain predicts and anticipates responses to the consumption of dietary substances, thus driving adaptive behaviors in the form of food choices, physiological preparation for meals, and engagement of defensive mechanisms. Here, we provide an integrative perspective on the multisensory computation between exteroceptive and interoceptive cues that guides feeding strategy and may result in food-related disorders.
大脑预测和预期内部和外部环境变化的能力对于启动有效的适应性反应、行为和反射至关重要，这些反应、行为和反射最大限度地减少了对生理的干扰。在进食控制的背景下，大脑预测和预期对饮食物质消耗的反应，从而以食物选择、对进餐的生理准备和防御机制参与的形式驱动适应性行为。在这里，我们提供了一个关于外感受和内感受线索之间的多感觉计算的综合视角，该计算指导进食策略，并可能导致与食物相关的障碍。
