Wu Qi, Wang Yifei, Wang Linxia, Su Yu, He Guorong, Chen Xiaojiang, Hou Lei, Zhang Wenyan, Wang Yao-Yu
Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, PR China.
International Joint Research Centre for the Battery-Free Internet of Things, Advanced Battery-Free Sensing and Computing Technology International Science and Technology Cooperation Base, Northwest University, Xi'an 710127, PR China.
ACS Appl Mater Interfaces. 2024 Oct 16;16(41):55802-55812. doi: 10.1021/acsami.4c13087. Epub 2024 Oct 3.
Constructing stable, portable sensors and revealing their mechanisms is challenging. Ion metal-organic frameworks (IMOFs) are poised to serve as highly effective electrochemical sensors for detecting organophosphorus pesticides (OPs), leveraging their unique charge properties. In this work, an amino-modified IMOF was constructed and combined with near-field communication (NFC) technology to develop a portable, touchless, and battery-free electrochemical biosensor . -NH in gives the framework a higher electropositivity compared to , enhancing the electrostatic attraction with acetylcholinesterase (AChE), which is beneficial for immobilizing AChE. Furthermore, the uncoordinated O atoms and the (CH)NH groups in help to form stronger bonds with AChE through hydrogen bonds. The results showed a wide linear response range of 1 × 10 to 1 × 10 M and a low detection limit of 1.24 × 10 M for glyphosate (Gly) in the practical detection of OPs. Additionally, electrochemical biosensor arrays were constructed to effectively identify and distinguish multiple OPs on the basis of their unique differential pulse voltammetry (DPV) electrochemical signals. This work provides a simple and effective solution for on-site OP analysis and can be widely applied in food safety and water quality monitoring.
构建稳定、便携的传感器并揭示其机制具有挑战性。离子金属有机框架（IMOFs）凭借其独特的电荷特性，有望成为检测有机磷农药（OPs）的高效电化学传感器。在这项工作中，构建了一种氨基修饰的IMOF，并与近场通信（NFC）技术相结合，开发出一种便携式、非接触式且无需电池的电化学生物传感器。与[未提及的对比对象]相比，[具体物质]中的-NH使框架具有更高的正电性，增强了与乙酰胆碱酯酶（AChE）的静电吸引力，这有利于固定AChE。此外，[具体物质]中未配位的O原子和(CH)NH基团有助于通过氢键与AChE形成更强的键。结果表明，在实际检测OPs时，对草甘膦（Gly）的线性响应范围为1×10至1×10 M，检测限低至1.24×10 M。此外，基于其独特的差分脉冲伏安法（DPV）电化学信号，构建了电化学生物传感器阵列，以有效识别和区分多种OPs。这项工作为现场OP分析提供了一种简单有效的解决方案，可广泛应用于食品安全和水质监测。
