Boskabadi Seyed Javad, Ramezaninejad Sima, Zakariaei Zakaria
Student Research Committee Pharmaceutical Sciences Research Center Faculty of Pharmacy Mazandaran University of Medical Sciences, Sari, Iran.
Toxicology and Forensic Medicine Division Mazandaran Registry Center for Opioids Poisoning Antimicrobial Resistance Research Center Imam Khomeini Hospital Mazandaran University of Medical Sciences, Sari, Iran.
Case Rep Neurol Med. 2024 Sep 26;2024:5411258. doi: 10.1155/2024/5411258. eCollection 2024.
(), commonly known as deadly nightshade, is a poisonous plant belonging to the Solanaceae family. The toxic effects of are attributable to its alkaloid content, which possesses potent anticholinergic properties. These alkaloids are responsible for the plant's toxicity and can cause a range of adverse effects in humans and animals upon ingestion or contact. In this report, we describe two atypical cases of poisoning resulting from accidental ingestion of the plant's raw leaves, which were referred to the emergency room of a poisoning center in northern Iran. Both patients presented with symptoms of anticholinergic toxicity, including dry mouth, mydriasis, tachycardia, and delirium. The patients were managed conservatively with supportive measures, including hydration and administration of benzodiazepines to control agitation and delirium. With appropriate treatment, both patients showed improvement and were discharged from the hospital. intoxication is associated with a range of clinical manifestations, primarily due to its neurotoxic effects. These manifestations may include flushing, mydriasis, tachycardia, ataxia, agitation, delirium, and urinary retention. The severity of symptoms can vary depending on the amount of the toxin ingested and the individual's susceptibility. In severe cases, toxicity can lead to seizures, coma, and even death. These cases highlight the importance of awareness regarding the potential toxicity of and the necessity of prompt and appropriate management of its toxicity. In severe cases, physostigmine may be considered for the treatment of neurological symptoms due to the plant's anticholinergic effects.
（），俗称颠茄，是一种属于茄科的有毒植物。其毒性作用归因于其生物碱含量，这些生物碱具有强大的抗胆碱能特性。这些生物碱是该植物毒性的原因，摄入或接触后会在人和动物身上引起一系列不良反应。在本报告中，我们描述了两起因意外摄入该植物生叶导致的非典型中毒病例，这些病例被转诊至伊朗北部一家中毒中心的急诊室。两名患者均出现抗胆碱能毒性症状，包括口干、瞳孔散大、心动过速和谵妄。对患者采取了保守治疗，包括支持措施，如补液以及使用苯二氮䓬类药物来控制躁动和谵妄。经过适当治疗，两名患者均有所好转并出院。中毒与一系列临床表现相关，主要是由于其神经毒性作用。这些表现可能包括脸红、瞳孔散大、心动过速、共济失调、躁动、谵妄和尿潴留。症状的严重程度可能因摄入毒素的量和个体易感性而异。在严重情况下，中毒可导致癫痫发作、昏迷甚至死亡。这些病例凸显了认识到其潜在毒性的重要性以及及时、适当处理其毒性的必要性。在严重情况下，由于该植物的抗胆碱能作用，可考虑使用毒扁豆碱来治疗神经症状。
