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肺结节病中枢纽基因的鉴定和验证。

Identification and validation of hub differential genes in pulmonary sarcoidosis.

机构信息

Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Clinical Research Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

出版信息

Front Immunol. 2024 Sep 19;15:1466029. doi: 10.3389/fimmu.2024.1466029. eCollection 2024.

DOI:10.3389/fimmu.2024.1466029
PMID:39364409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11446782/
Abstract

A total of 138 cDEGs were screened from mediastinal lymph nodes and peripheral whole blood. Among them, 6 hub cDEGs including CTSS, CYBB, FPR2, MNDA, TLR1 and TLR8 with elevated degree and betweenness levels were illustrated in protein-protein interaction network. In comparison to healthy controls, CTSS (1.61 vs. 1.05), CYBB (1.68 vs. 1.07), FPR2 (2.77 vs. 0.96), MNDA (2.14 vs. 1.23), TLR1 (1.56 vs. 1.09), and TLR8 (2.14 vs. 0.98) displayed notably elevated expression levels within pulmonary sarcoidosis PBMC samples (P < 0.0001 for FPR2 and P < 0.05 for others), echoing with prior mRNA microarray findings. The most significant functional pathways were immune response, inflammatory response, plasma membrane and extracellular exosome, with 6 hub cDEGs distributing along these pathways. CTSS, CYBB, FPR2, MNDA, TLR1, and TLR8 could be conducive to improving the diagnostic process and understanding the underlying mechanisms of pulmonary sarcoidosis.

摘要

共从纵隔淋巴结和外周全血筛选出 138 个差异表达基因。其中，CTSS、CYBB、FPR2、MNDA、TLR1 和 TLR8 这 6 个上调程度和介数较高的 hub 差异表达基因在蛋白质-蛋白质相互作用网络中被描绘出来。与健康对照组相比，肺结节病 PBMC 样本中 CTSS（1.61 比 1.05）、CYBB（1.68 比 1.07）、FPR2（2.77 比 0.96）、MNDA（2.14 比 1.23）、TLR1（1.56 比 1.09）和 TLR8（2.14 比 0.98）表达水平显著升高（FPR2 为 P < 0.0001，其他为 P < 0.05），与先前的 mRNA 微阵列研究结果一致。最显著的功能途径是免疫反应、炎症反应、质膜和细胞外外泌体，这 6 个 hub 差异表达基因分布在这些途径中。CTSS、CYBB、FPR2、MNDA、TLR1 和 TLR8 可能有助于改善肺结节病的诊断过程和理解其潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8129/11446782/b17f913748b7/fimmu-15-1466029-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8129/11446782/5a4b2ef87e82/fimmu-15-1466029-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8129/11446782/34fbd3000656/fimmu-15-1466029-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8129/11446782/18460a5a74c7/fimmu-15-1466029-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8129/11446782/512f83fe8b33/fimmu-15-1466029-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8129/11446782/b17f913748b7/fimmu-15-1466029-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8129/11446782/5a4b2ef87e82/fimmu-15-1466029-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8129/11446782/34fbd3000656/fimmu-15-1466029-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8129/11446782/18460a5a74c7/fimmu-15-1466029-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8129/11446782/512f83fe8b33/fimmu-15-1466029-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8129/11446782/b17f913748b7/fimmu-15-1466029-g005.jpg

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本文引用的文献

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Role of Bronchoscopy in Diagnosis of Sarcoidosis.支气管镜检查在结节病诊断中的作用。
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