Iwamoto Yuichiro, Kimura Tomohiko, Katakura Yukino, Tatsumi Fuminori, Shimoda Masashi, Nakanishi Shuhei, Mune Tomoatsu, Kaku Kohei, Kaneto HIdeaki
Department of Diabetes, Endocrinology, and Metabolism, Kawasaki Medical School, Kurashiki, JPN.
Cureus. 2024 Sep 3;16(9):e68567. doi: 10.7759/cureus.68567. eCollection 2024 Sep.
Aim Chronic hyperglycemia is a well-known risk factor for the development of many macrovascular complications, but hyperglycemia may be reportedly protective against abdominal aneurysms. Materials and methods In this study, we evaluated morphological differences in the abdominal aorta between subjects with and without type 2 diabetes mellitus (T2DM) without abdominal aortic aneurysm and evaluated the correlation between imaging findings of computed tomography (CT) and diabetes-related parameters. Results The abdominal aortic diameter was significantly smaller in subjects with T2DM compared to non-diabetes mellitus (NDM) subjects (p=0.026). Abdominal aortic wall thickness assessed by contrast-enhanced CT was significantly greater in subjects with T2DM compared to NDM subjects (p=0.011). There was a significant single correlation between abdominal aortic diameter and age, gender, Brinkman index, HbA1c, and mean/max intima-media thickness (IMT). Multiple regression analysis showed that HbA1c was an independent negative factor affecting abdominal aortic diameter (t=-3.28, p=0.0036). And Brinkmann index was an independent factor affecting aortic wall thickness (t=2.23, p=0.034). Conclusion This study revealed the imaging characteristics of smaller abdominal aortic diameter and larger wall thickness in T2DM subjects compared to NDM subjects. The abdominal aortic wall thickening was significantly correlated with cervical IMT. Therefore, close examination for other diabetes-related macrovascular complications should be aggressively considered when these findings are present.
目的 慢性高血糖是多种大血管并发症发生的一个众所周知的危险因素，但据报道高血糖可能对腹主动脉瘤具有保护作用。材料与方法 在本研究中，我们评估了无腹主动脉瘤的2型糖尿病（T2DM）患者和非糖尿病患者腹主动脉的形态学差异，并评估了计算机断层扫描（CT）成像结果与糖尿病相关参数之间的相关性。结果 与非糖尿病（NDM）患者相比，T2DM患者的腹主动脉直径显著更小（p = 0.026）。与NDM患者相比，通过增强CT评估的T2DM患者的腹主动脉壁厚度显著更大（p = 0.011）。腹主动脉直径与年龄、性别、布林克曼指数、糖化血红蛋白（HbA1c）以及平均/最大内膜中层厚度（IMT）之间存在显著的单因素相关性。多元回归分析表明，HbA1c是影响腹主动脉直径的一个独立负性因素（t = -3.28，p = 0.0036）。并且布林克曼指数是影响主动脉壁厚度的一个独立因素（t = 2.23，p = 0.034）。结论 本研究揭示了与NDM患者相比，T2DM患者腹主动脉直径更小且壁厚度更大的影像学特征。腹主动脉壁增厚与颈动脉IMT显著相关。因此，当出现这些发现时，应积极考虑对其他糖尿病相关大血管并发症进行密切检查。
