Department of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Department of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Neuropeptides. 2024 Dec;108:102475. doi: 10.1016/j.npep.2024.102475. Epub 2024 Sep 29.
Epilepsy is a common neurological condition characterized by abnormal neuronal activity, often leading to cellular damage and death. There is evidence to suggest that lipid imbalances resulting in cellular death play a key role in the development of epilepsy, including changes in triglycerides, cholesterol, sphingolipids, phospholipids, lipid droplets, and bile acids (BAs). Disrupted lipid metabolism acts as a crucial pathological mechanism in epilepsy, potentially linked to processes such as cellular ferroptosis, lipophagy, and immune modulation of gut microbiota (thus influencing the gut-brain axis). Understanding these mechanisms could open up new avenues for epilepsy treatment. This study investigates the association between disturbances in lipid metabolism and the onset of epilepsy.
癫痫是一种常见的神经系统疾病，其特征是神经元活动异常，通常导致细胞损伤和死亡。有证据表明，脂质失衡导致细胞死亡在癫痫的发展中起着关键作用，包括甘油三酯、胆固醇、神经鞘脂、磷脂、脂滴和胆汁酸 (BAs) 的变化。脂质代谢紊乱是癫痫的一个重要病理机制，可能与细胞铁死亡、脂噬和肠道微生物群免疫调节等过程有关（从而影响肠道-大脑轴）。了解这些机制可能为癫痫治疗开辟新途径。本研究探讨了脂质代谢紊乱与癫痫发作之间的关系。
