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Exhausted CD8 T cells and anti-inflammatory macrophages characterize lepromatous leprosy lesions.

作者信息

Mayer-Barber Katrin D, Barber Daniel L, Via Laura E

机构信息

Inflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.

T Lymphocyte Biology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, 20892, USA.

出版信息

EBioMedicine. 2024 Nov;109:105382. doi: 10.1016/j.ebiom.2024.105382. Epub 2024 Oct 3.

DOI:10.1016/j.ebiom.2024.105382
PMID:39366250
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11489073/
Abstract
摘要

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Exhausted CD8 T cells and anti-inflammatory macrophages characterize lepromatous leprosy lesions.耗竭的CD8 T细胞和抗炎性巨噬细胞是瘤型麻风病损的特征。
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Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics.单细胞多模态组学揭示麻风肉芽肿中细菌负担的细胞和分子决定因素。
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本文引用的文献

1
Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics.单细胞多模态组学揭示麻风肉芽肿中细菌负担的细胞和分子决定因素。
EBioMedicine. 2024 Oct;108:105342. doi: 10.1016/j.ebiom.2024.105342. Epub 2024 Sep 24.
2
Metformin as adjunctive therapy in combination with multidrug treatment for multibacillary leprosy: A protocol for a randomized double-blind, controlled Phase 2 trial in Indonesia (MetLep Trial).二甲双胍作为多菌型麻风联合多药治疗的辅助疗法：印度尼西亚一项随机双盲对照2期试验方案（MetLep试验）
Wellcome Open Res. 2024 May 9;8:289. doi: 10.12688/wellcomeopenres.19455.2. eCollection 2023.
3
Genome-wide meta-analysis and fine-mapping prioritize potential causal variants and genes related to leprosy.全基因组荟萃分析和精细定位确定了与麻风病相关的潜在因果变异和基因。
MedComm (2020). 2023 Nov 24;4(6):e415. doi: 10.1002/mco2.415. eCollection 2023 Dec.
4
Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data.多基因富集可区分单细胞 RNA-seq 数据中单个细胞的疾病关联。
Nat Genet. 2022 Oct;54(10):1572-1580. doi: 10.1038/s41588-022-01167-z. Epub 2022 Sep 1.
5
Leprosy in wild chimpanzees.野生黑猩猩中的麻风病。
Nature. 2021 Oct;598(7882):652-656. doi: 10.1038/s41586-021-03968-4. Epub 2021 Oct 13.
6
Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes.从新的古代基因组看中世纪欧洲麻风分枝杆菌的多样性和种群动态。
BMC Biol. 2021 Oct 5;19(1):220. doi: 10.1186/s12915-021-01120-2.
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Evidence of zoonotic leprosy in Pará, Brazilian Amazon, and risks associated with human contact or consumption of armadillos.巴西亚马逊帕拉州动物源麻风病的证据，以及人类接触或食用犰狳相关的风险。
PLoS Negl Trop Dis. 2018 Jun 28;12(6):e0006532. doi: 10.1371/journal.pntd.0006532. eCollection 2018 Jun.
8
Long-term survival and virulence of Mycobacterium leprae in amoebal cysts.麻风分枝杆菌在变形虫囊肿中的长期存活及毒力
PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3405. doi: 10.1371/journal.pntd.0003405. eCollection 2014 Dec.