PKM2-G-四链体相互作用协同调节癌症转录组。

PKM2-G-quadruplex interactions conspire to regulate the cancer transcriptome.

机构信息

Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Mol Cell. 2024 Oct 3;84(19):3574-3575. doi: 10.1016/j.molcel.2024.09.013.

DOI:10.1016/j.molcel.2024.09.013

PMID:39366344

Abstract

In this issue of Molecular Cell, Anastasakis et al. describe a novel function of the metabolic enzyme PKM2 as an RNA G-quadruplex binding protein, which could contribute to cancer biology.

摘要

在本期《分子细胞》中，Anastasakis 等人描述了代谢酶 PKM2 作为 RNA G-四链体结合蛋白的新功能，这可能有助于癌症生物学研究。