Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, China; Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China; Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China; Research Center of Molecular Metabolomics, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, China; Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China; Xiangya Clinical Research Center for Cancer Immunotherapy, Central South University, Changsha, Hunan, China; Research Center of Molecular Metabolomics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Cancer Lett. 2021 Apr 10;503:240-248. doi: 10.1016/j.canlet.2020.11.018. Epub 2020 Nov 24.
Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, is a critical regulator in tumor metabolism. PKM2 has been demonstrated to overexpressed in various cancers and promoted proliferation and metastasis of tumor cells. The errant expression of PKM2 has inspired people to investigate the function of PKM2 and the therapeutic potential in cancer. In addition, some studies have shown that the upregulation of PKM2 in tumor tissues is associated with the altered expression of lncRNAs and the poor survival. Therefore, researchers have begun to unravel the specific molecular mechanisms of lncRNA-mediated PKM2 expression in cancer metabolism. As the tumor microenvironment (TME) is essential in tumor development, it is necessary to identify the role of PKM2 in TME. In this review, we will introduce the role of PKM2 in different cancers as well as TME, and summarize the molecular mechanism of PKM2-related lncRNAs in cancer metabolism. We expect that this work will lead to a better understanding of the molecular mechanisms of PKM2 that may help in developing therapeutic strategies in clinic for researchers.
丙酮酸激酶 M2（PKM2）是糖酵解的关键限速酶，是肿瘤代谢中的关键调节因子。PKM2 在各种癌症中过度表达，并促进肿瘤细胞的增殖和转移。PKM2 的异常表达激发了人们对 PKM2 的功能及其在癌症中的治疗潜力的研究。此外，一些研究表明，肿瘤组织中 PKM2 的上调与 lncRNAs 的表达改变和不良预后有关。因此，研究人员已经开始揭示 lncRNA 介导的 PKM2 在癌症代谢中的表达的具体分子机制。由于肿瘤微环境（TME）在肿瘤发展中至关重要，因此有必要确定 PKM2 在 TME 中的作用。在这篇综述中，我们将介绍 PKM2 在不同癌症以及 TME 中的作用，并总结 PKM2 相关 lncRNAs 在癌症代谢中的分子机制。我们希望这项工作将有助于更好地理解 PKM2 的分子机制，这可能有助于研究人员在临床上开发治疗策略。
