PRC2-RNA 相互作用：吉米·郭、马里奥·R·布兰科和米切尔·古特曼的观点。

PRC2-RNA interactions: Viewpoint from Jimmy K. Guo, Mario R. Blanco, and Mitchell Guttman.

机构信息

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

出版信息

Mol Cell. 2024 Oct 3;84(19):3578-3585. doi: 10.1016/j.molcel.2024.09.007.

DOI:10.1016/j.molcel.2024.09.007

PMID:39366346

Abstract

Many reported PRC2-RNA interactions have been shown to be functionally dispensable, raising questions about whether they occur in vivo. Here, we lay out technical issues with existing evidence for direct binding and argue that there is currently a lack of biochemical or functional evidence for direct PRC2-RNA binding in vivo.

摘要

许多报道的 PRC2-RNA 相互作用已被证明在功能上是可有可无的，这引发了关于它们是否在体内发生的问题。在这里，我们列出了现有直接结合证据的技术问题，并认为目前缺乏体内直接 PRC2-RNA 结合的生化或功能证据。