PRC2-RNA 相互作用：来自 Tom Cech、Chen Davidovich 和 Richard Jenner 的观点。

PRC2-RNA interactions: Viewpoint from Tom Cech, Chen Davidovich, and Richard Jenner.

机构信息

Department of Biochemistry, BioFrontiers Institute, and Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309, USA.

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton 3800 VIC, Australia; EMBL-Australia, Clayton 3800 VIC, Australia.

出版信息

Mol Cell. 2024 Oct 3;84(19):3593-3595. doi: 10.1016/j.molcel.2024.09.010.

DOI:10.1016/j.molcel.2024.09.010

PMID:39366348

Abstract

Diverse biochemical, structural, and in vivo data support models for the regulation of polycomb repressive complex 2 (PRC2) activity by RNAs, which may contribute to the maintenance of epigenetic states. Here, we summarize this research and also suggest why it can be difficult to capture biologically relevant PRC2-RNA interactions in living cells.

摘要

多样化的生化、结构和体内数据支持 RNA 调控多梳抑制复合物 2 (PRC2) 活性的模型，这可能有助于维持表观遗传状态。在这里，我们总结了这方面的研究，并提出了为什么在活细胞中很难捕获具有生物学相关性的 PRC2-RNA 相互作用的原因。