Institute of Biochemistry, FB08, Justus Liebig University, 35392 Giessen, Germany.
Institute of Biochemistry, FB08, Justus Liebig University, 35392 Giessen, Germany; Cardio-Pulmonary Institute (CPI), EXC 2026, 35392 Giessen, Germany.
Mol Cell. 2024 Oct 3;84(19):3681-3691. doi: 10.1016/j.molcel.2024.08.028.
Nuclear messenger RNA (mRNA) export is vital for cell survival under both physiological and stress conditions. To cope with stress, cells block bulk mRNA export while selectively exporting stress-specific mRNAs. Under physiological conditions, nuclear adaptor proteins recruit the mRNA exporter to the mRNA for export. By contrast, during stress conditions, the mRNA exporter is likely directly recruited to stress-specific mRNAs at their transcription sites to facilitate selective mRNA export. In this review, we summarize our current understanding of nuclear mRNA export. Importantly, we explore insights into the mechanisms that block bulk mRNA export and facilitate transcript-specific mRNA export under stress, highlighting the gaps that still need to be filled.
核信使 RNA（mRNA）的输出对于生理和应激条件下的细胞存活至关重要。为了应对应激，细胞会阻断大量 mRNA 的输出，而选择性地输出应激特异性的 mRNAs。在生理条件下，核衔接蛋白将 mRNA 输出器募集到 mRNA 上以进行输出。相比之下，在应激条件下，mRNA 输出器可能直接在其转录位点被募集到应激特异性 mRNAs 上，以促进选择性的 mRNA 输出。在这篇综述中，我们总结了我们对核 mRNA 输出的现有认识。重要的是，我们探讨了在应激下阻止大量 mRNA 输出和促进转录特异性 mRNA 输出的机制的见解，突出了仍然需要填补的空白。
