肥胖受试者对持续输注人胰生长激素释放因子1 - 44的反应。

The response of obese subjects to continuous infusion of human pancreatic growth hormone-releasing factor 1-44.

作者信息

Davies R R, Turner S J, Cook D, Alberti K G, Johnston D G

出版信息

Clin Endocrinol (Oxf). 1985 Nov;23(5):521-5. doi: 10.1111/j.1365-2265.1985.tb01112.x.

DOI:10.1111/j.1365-2265.1985.tb01112.x

Abstract

The growth hormone (GH) response of seven obese subjects to a 4 h continuous infusion of human pancreatic GH-releasing factor, 0.3 micrograms/kg/h, has been compared with that obtained in seven sex and age matched controls. The pattern of response was normal in the obese but peak GH levels (mean +/- SEM: 13.8 +/- 1.9 compared to 30.9 +/- 4.7 mU/l, P less than 0.01) and integrated GH levels (mean +/- SEM: 27.1 +/- 3.6 compared to 62.0 +/- 9.7 mU/l/h, P less than 0.01) were reduced in obese subjects. There was a negative correlation between the integrated GH response and the percentage ideal body weight (r = -0.80, P less than 0.05), but no significant correlation with somatomedin-C levels (r = +0.72; P = 0.07). Obese subjects have an impaired GH response to infusion of GH-releasing factor which is not related to negative feedback by somatomedins.

摘要

将7名肥胖受试者对以0.3微克/千克/小时的速度连续输注4小时人胰腺生长激素释放因子的生长激素（GH）反应，与7名性别和年龄匹配的对照者的反应进行了比较。肥胖者的反应模式正常，但肥胖受试者的GH峰值水平（平均值±标准误：13.8±1.9，而对照者为30.9±4.7 mU/l，P<0.01）和GH积分水平（平均值±标准误：27.1±3.6，而对照者为62.0±9.7 mU/l/小时，P<0.01）降低。GH积分反应与理想体重百分比之间存在负相关（r = -0.80，P<0.05），但与生长调节素-C水平无显著相关性（r = +0.72；P = 0.07）。肥胖受试者对生长激素释放因子输注的GH反应受损，这与生长调节素的负反馈无关。