Davies R R, Turner S J, Parkin J M, Johnston D G
Clin Endocrinol (Oxf). 1984 Nov;21(5):569-74. doi: 10.1111/j.1365-2265.1984.tb01396.x.
The GH response to a prolonged continuous infusion of human pancreatic growth hormone releasing factor (hpGRF 1-44), 0.3 microgram/kg/h was evaluated in seven patients with severe idiopathic GH deficiency, one patient with partial deficiency and in seven normal controls. Normal controls had a multiphasic response with a first peak between 15 and 90 min of 13.6 to 88.5, mean 45.6 mU/l and a second peak between 105 and 195 min of 8.8 to 73.1, mean 33.8 mU/l. However, the magnitude and pattern of response were highly variable. Six of the seven patients with severe GH deficiency had a response with a maximum level between 30 and 90 min of 3.3 to 7.5, mean 4.8 mU/l. Mean levels remained greater than 2.0 mU/l throughout the infusion but further peaks were absent or minimal. The patient with partial GH deficiency responded in a normal manner. hpGRF 1-44 by continuous infusion thus induced GH release in seven of eight patients with idiopathic GH deficiency though the response was impaired and the pattern of secretion abnormal in severely deficient patients.
对7例严重特发性生长激素缺乏症患者、1例部分生长激素缺乏症患者以及7名正常对照者，评估了生长激素对持续输注0.3微克/千克/小时人胰腺生长激素释放因子（hpGRF 1-44）的反应。正常对照者的反应呈多相性，第一个峰值出现在15至90分钟之间，为13.6至88.5，平均45.6 mU/l，第二个峰值出现在105至195分钟之间，为8.8至73.1，平均33.8 mU/l。然而，反应的幅度和模式差异很大。7例严重生长激素缺乏症患者中有6例的反应峰值出现在30至90分钟之间，为3.3至7.5，平均4.8 mU/l。在整个输注过程中，平均水平保持高于2.0 mU/l，但没有进一步的峰值或峰值极小。部分生长激素缺乏症患者的反应正常。因此，持续输注hpGRF 1-44可诱导8例特发性生长激素缺乏症患者中的7例释放生长激素，尽管严重缺乏症患者的反应受损且分泌模式异常。
