干扰素可诱导原发性慢性淋巴细胞白血病细胞增殖和分化。
Interferon induces proliferation and differentiation in primary chronic lymphocytic leukaemia cells.
作者信息
Robert K H, Einhorn S, Juliusson G, Ostlund L, Biberfeld P
出版信息
Clin Exp Immunol. 1985 Dec;62(3):530-4.
Abstract
The influence of interferon-alpha (IFN-alpha) on the differentiation of malignant cells from six patients with chronic lymphocytic leukaemia was studied in vitro. IFN induced differentiation in the leukaemic cells from four of the patients. In cells from two of these patients, IFN also induced proliferation. When tested by immunofluorescence, the clonality of the differentiating cells was established by the presence of intracellular light chains of one type only.
摘要
研究了α-干扰素（IFN-α）对6例慢性淋巴细胞白血病患者恶性细胞分化的体外影响。IFN诱导了4例患者白血病细胞的分化。在其中2例患者的细胞中，IFN还诱导了增殖。通过免疫荧光检测，分化细胞的克隆性仅通过一种类型的细胞内轻链的存在得以确定。
Zotero 插件