Li Bohao, Wen Mingxin, Gao Fei, Wang Yunshan, Wei Guangwei, Duan Yangmiao
Department of Cell Biology and Key Laboratory of Experimental Teratology, Ministry of Education, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Department of Anatomy, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Cell Death Discov. 2024 Oct 4;10(1):427. doi: 10.1038/s41420-024-02198-7.
Heterogeneous nuclear ribonucleoproteins (HNRNPs) represent a large family of RNA-binding proteins consisting of more than 20 members and have attracted great attention with their distinctive roles in cancer progression by regulating RNA splicing, transcription, and translation. Nevertheless, the cancer-specific modulation of HNRNPs has not been fully elucidated. The research of LC-MS/MS technology has documented that HNRNPs were widely and significantly targeted by different post-translational modifications (PTMs), which have emerged as core regulators in shaping protein functions and are involved in multiple physiological processes. Accumulating studies have highlighted that several PTMs are involved in the mechanisms of HNRNPs regulation in cancer and may be suitable therapeutic targets. In this review, we summarize the existing evidence describing how PTMs modulate HNRNPs functions on gene regulation and the involvement of their dysregulation in cancer, which will help shed insights on their clinical impacts as well as possible therapeutic tools targeting PTMs on HNRNPs.
不均一核核糖核蛋白（HNRNPs）是一个由20多个成员组成的大型RNA结合蛋白家族，它们通过调节RNA剪接、转录和翻译在癌症进展中发挥独特作用，因而备受关注。然而，HNRNPs在癌症中的特异性调节作用尚未完全阐明。液相色谱-串联质谱（LC-MS/MS）技术研究表明，HNRNPs受到不同翻译后修饰（PTMs）的广泛且显著靶向作用，这些修饰已成为塑造蛋白质功能的核心调节因子，并参与多种生理过程。越来越多的研究强调，几种PTMs参与了癌症中HNRNPs的调节机制，可能是合适的治疗靶点。在本综述中，我们总结了现有证据，描述了PTMs如何调节HNRNPs在基因调控上的功能以及它们的失调在癌症中的作用，这将有助于深入了解它们的临床影响以及针对HNRNPs上PTMs的可能治疗工具。
