Su J H, Aso T, Matsuoka M, Horie K, Nishimura T
Endocrinol Jpn. 1985 Aug;32(4):455-62. doi: 10.1507/endocrj1954.32.455.
To Clarify the relationship between the time interval and pituitary Luteinizing hormone (LH), Follicular stimulation hormone (FSH) and prolactin (PRL) secretion function under LHRH-TRH stimulation, 4 mature female baboons were used. Two consecutive LHRH (100 micrograms)-TRH (250 micrograms) stimulations with a 60 min interval between them was carried out in the early follicular phase, late follicular phase and mid luteal phase in the same baboon in the first menstrual cycle, then carried out with a 120 min interval between tests in the third menstrual cycle. The LH, FSH and PRL were measured by specific radioimmunoassay. The PRL maximum response to the first bolus of TRH was higher than maximum response to the second bolus of TRH. The PRL maximum response to the second TRH at a 120 min interval was higher than the maximum response to the second TRH at a 60 min interval. It seems that the TRH had the dominant effect on PRL releasing but not on PRL Priming. The maximum LH response to the second bolus of LHRH was higher than the maximum response to the first bolus of LHRH. The LH maximum response to the second bolus of LHRH at a 60 min interval was greater than the maximum response at a 120 min interval in the follicular phase but it was the reverse in the luteal phase. The FSH response to the second LHRH was different from the LH response.(ABSTRACT TRUNCATED AT 250 WORDS)
为阐明促性腺激素释放激素-促甲状腺激素释放激素（LHRH-TRH）刺激下时间间隔与垂体促黄体生成素（LH）、促卵泡刺激素（FSH）及催乳素（PRL）分泌功能之间的关系，选用了4只成年雌性狒狒。在第一月经周期的同一狒狒的卵泡早期、卵泡晚期及黄体中期，进行两次连续的LHRH（100微克）-TRH（250微克）刺激，两次刺激间隔60分钟，然后在第三月经周期的测试中，两次刺激间隔120分钟。采用特异性放射免疫分析法测定LH、FSH和PRL。PRL对首次TRH推注的最大反应高于对第二次TRH推注的最大反应。间隔120分钟时对第二次TRH的PRL最大反应高于间隔60分钟时对第二次TRH的最大反应。似乎TRH对PRL释放有主导作用，但对PRL启动无主导作用。LH对第二次LHRH推注 的最大反应高于对第一次LHRH推注的最大反应。在卵泡期，间隔60分钟时LH对第二次LHRH推注的最大反应大于间隔120分钟时的最大反应，但在黄体期情况相反。FSH对第二次LHRH的反应与LH反应不同。（摘要截选至250词）
