Sumran Garima, Sharma Manisha, Aggarwal Ranjana
Department of Chemistry, D. A. V. College (Lahore), Ambala City, Haryana, India.
Department of Chemistry, Kurukshetra University, Kurukshetra, India.
Arch Pharm (Weinheim). 2024 Dec;357(12):e2400576. doi: 10.1002/ardp.202400576. Epub 2024 Oct 4.
Several pyrazole-thiazole hybrids featuring two potentially bioactive pharmacophores with or without linker have been synthesized using the molecular hybridization approach as target structures by medicinal chemists to modulate multiple drug targets simultaneously. The presented review aims to provide an overview of the diversified and wide array of pharmacological activities of these hybrids bestowing anticancer, antifungal, antibacterial, analgesic, anti-inflammatory, antioxidant, antitubercular, antiviral, antiparasitic, and miscellaneous activities. The structure-activity relationships and potential mechanism of action are also reviewed to shed light on the development of more effective and biotargeted candidates. This review focuses on the latest research advances in the biological profile of pyrazole-thiazole hybrids reported from 2015 to the present, providing medicinal researchers with a comprehensive platform to rationally design and develop more promising pyrazole-thiazole hybrids.
药用化学家利用分子杂交方法合成了几种具有两个潜在生物活性药效基团、带有或不带有连接子的吡唑 - 噻唑杂化物，将其作为目标结构以同时调节多个药物靶点。本综述旨在概述这些杂化物多样化且广泛的药理活性，包括抗癌、抗真菌、抗菌、镇痛、抗炎、抗氧化、抗结核、抗病毒、抗寄生虫以及其他各种活性。还综述了构效关系和潜在作用机制，以阐明更有效且针对生物靶点的候选药物的开发情况。本综述聚焦于2015年至今报道的吡唑 - 噻唑杂化物生物学特性的最新研究进展，为药物研究人员提供一个全面的平台，以便合理设计和开发更有前景的吡唑 - 噻唑杂化物。
