Bendi Anjaneyulu, Devi Poonam, Sharma Harsh, Yadav Geetanjali, Raghav Neera, Pundeer Rashmi, Afshari Mozhgan
Innovation and Translational Research Hub (iTRH) & Department of Chemistry, Presidency University, Bangalore, Karnataka, India.
Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India.
Chem Biodivers. 2025 Apr;22(4):e202402370. doi: 10.1002/cbdv.202402370. Epub 2024 Dec 23.
Heterocyclic compounds that include nitrogen and their derivatives have long been regarded as excellent sources of medicinal substances. Pyrazole is a compound with two nitrogen atoms and an aromatic structure. It has several uses and intricate stereochemistry arranged in a five-membered ring. The knowledge of different pyrazole derivatives and their range of physiological and pharmacological actions has grown significantly in recent years. The scientific community has recently increasingly focused on exploring the chemistry of various pyrazole hybrids due to their enhanced biological activities. This review investigates the chemistry of these diverse pyrazole hybrids, emphasizing their synthesis and their antidiabetic, antibacterial, anticancer, antimicrobial, antioxidant, and anti-inflammatory activities. Articles published from 2014 onward with an emphasis on the last 5 years are included in this review. This review is anticipated to be useful for future investigations and innovative concepts in the pursuit of designs for creating more promising hybrids of pyrazoles.
含有氮的杂环化合物及其衍生物长期以来一直被视为优良的药物来源。吡唑是一种含有两个氮原子和芳香结构的化合物。它有多种用途，其复杂的立体化学结构排列在一个五元环中。近年来，关于不同吡唑衍生物及其生理和药理作用范围的知识有了显著增长。由于其增强的生物活性，科学界最近越来越关注探索各种吡唑杂化物的化学性质。本综述研究了这些不同吡唑杂化物的化学性质，重点关注它们的合成以及抗糖尿病、抗菌、抗癌、抗微生物、抗氧化和抗炎活性。本综述纳入了2014年及以后发表的文章，重点是过去5年的文献。预计本综述将有助于未来的研究以及在设计更有前景的吡唑杂化物方面的创新理念。
