Lim Sharoen Yu Ming, Lim Willone, Peter Angela Paul, Pan Yan, Alshagga Mustafa, Alshawsh Mohammed Abdullah
Division of Biomedical Sciences, School of Pharmacy, University of Nottingham Malaysia, Semenyih, Selangor, Malaysia.
Faculty of Business, Design and Arts, Swinburne University of Technology, Kuching, Sarawak, Malaysia.
J Appl Toxicol. 2025 May;45(5):714-720. doi: 10.1002/jat.4707. Epub 2024 Oct 4.
The CYP33 family in Caenorhabditis elegans is integral to processes like xenobiotic detoxification, eicosanoid regulation, nanotoxicity response and spermatogenesis. Limited research on C. elegans CYP33 suggests its functions are similar to human CYP33, indicating conserved roles in metabolism and disease. This review examines C. elegans CYP33 enzymes, especially CYP-33E1 and CYP-33E2, and their human homologues, focusing on their roles in eicosanoid biosynthesis, xenobiotic metabolism, nanotoxicity and spermatogenesis. Understanding these enzymes enhances insights into cytochrome P450 biology, metabolism and cyp-associated diseases.
