Holland Robert A, Crossthwaite Andrew
Syngenta, Bioscience, Jealott's Hill International Research Centre, Bracknell, UK.
Pest Manag Sci. 2025 May;81(5):2424-2426. doi: 10.1002/ps.8462. Epub 2024 Oct 5.
Insecticides targeting the nervous system have been the most widely used to control arthropod pests due to their fast onset of action leading to efficient crop protection. With their continued use, resistance has and will become an inevitable challenge that demands continued efforts in identifying and developing new insecticidal chemistries acting on novel targets. In a recent publication, the results of a comprehensive study investigating the mode of action of novel chemical scaffolds based on the 2-(3-ethylsulfonyl-2-pyridyl)-heterocycles, alkylsulfones, was presented, concluding that their primary target is the vesicular acetylcholine transporter. © 2024 Society of Chemical Industry.
由于作用迅速能有效保护作物，针对神经系统的杀虫剂一直是控制节肢动物害虫最广泛使用的方法。随着它们的持续使用，抗性已经并将成为一个不可避免的挑战，这需要持续努力来识别和开发作用于新靶点的新型杀虫化学物质。在最近的一篇出版物中，展示了一项全面研究的结果，该研究调查了基于2-(3-乙基磺酰基-2-吡啶基)-杂环、烷基砜的新型化学支架的作用模式，得出结论其主要靶点是囊泡乙酰胆碱转运体。© 2024化学工业协会。
