Clinic for Radiation Oncology & Medical Oncology, Small Animal Department, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Vet Comp Oncol. 2024 Dec;22(4):457-469. doi: 10.1111/vco.13011. Epub 2024 Oct 5.
Increasing numbers of dogs and cats with cancer are treated with stereotactic radiosurgery, stereotactic radiation therapy or stereotactic body radiotherapy (SRS, SRT or SBRT). We provide a systematic review of the current data landscape with a focus on technical and dosimetric data of stereotactic radiotherapy in veterinary oncology. Original peer-reviewed articles on dogs and cats with cancer treated with SRT were included. The systematic search included Medline via PubMed and EMBASE. The study was performed according to the Preferred Reporting Items for Systematic Reviews (PRISMA) statement. We assessed the manuscripts regarding outcome reporting, treatment planning, dose prescription, -delivery and -reporting as well as quality assurance. As of February 2024, there are 80 peer-reviewed publications on various disease entities on SRS, SRT and SBRT in veterinary medicine. Overall, we found often insufficient or highly variable technical data, with incomplete information to reproduce these treatments. While in some instances, technical factors may not impact clinical outcome, the variability found in protocols, outcome and toxicity assessments precludes accurate and reliable conclusions for a benefit of stereotactic radiotherapy for many of the treated diseases. In line with the extensive recommendations from human stereotactic radiotherapy practise, we propose a draft of reporting items for future stereotactic radiation treatments in veterinary medicine. SRS, SRT and SBRT have specific clinical and technological requirements that differ from those of standard radiation therapy. Therefore, a deep understanding of the methodologies, as well as the quality and precision of dose delivery, is essential for effective clinical knowledge transfer.
越来越多患有癌症的狗和猫接受立体定向放射手术、立体定向放射治疗或立体定向体放射治疗（SRS、SRT 或 SBRT）治疗。我们对当前数据进行了系统回顾，重点关注兽医肿瘤学中立体定向放射治疗的技术和剂量学数据。纳入了关于接受 SRT 治疗的癌症犬和猫的原始同行评审文章。系统搜索包括 Medline 通过 PubMed 和 EMBASE。该研究根据系统评价的首选报告项目（PRISMA）声明进行。我们评估了手稿中关于结果报告、治疗计划、剂量规定、-传递和-报告以及质量保证的内容。截至 2024 年 2 月，在兽医领域，有 80 篇关于 SRS、SRT 和 SBRT 各种疾病实体的同行评审出版物。总的来说，我们发现技术数据往往不足或高度可变，缺乏重现这些治疗的完整信息。虽然在某些情况下，技术因素可能不会影响临床结果，但在协议、结果和毒性评估中发现的可变性使得许多接受治疗的疾病的立体定向放射治疗的益处无法得出准确可靠的结论。根据人类立体定向放射治疗实践的广泛建议，我们提出了兽医立体定向放射治疗报告项目的草案。SRS、SRT 和 SBRT 具有不同于标准放射治疗的特定临床和技术要求。因此，深入了解方法学以及剂量传递的质量和精度对于有效的临床知识转移至关重要。
