Ocean College, Zhejiang University, Zhoushan 316021, China.
Proya Cosmetics Company, Ltd., Hangzhou 321000, China.
J Org Chem. 2024 Oct 18;89(20):15264-15270. doi: 10.1021/acs.joc.4c02067. Epub 2024 Oct 5.
Three new unusual citrinin derivatives with a unique 6/5/7/5 core, dicitrinols A-C (-, respectively), were isolated via the fermentation of hydrothermal vent-associated fungus TW132-59. Their structures were unambiguously determined by nuclear magnetic resonance, mass spectrometry, and electronic circular dichroism calculations. Dicitrinols A-C represent a novel cage carbon skeleton with a decahydro-5,9,4-(epipropane[1,1,3]triyl)cycloocta[]furan ring system. Dicitrinols A-C showed moderate antifungal activity against , , and and antibacterial activity against , , and with minimum inhibitory concentrations ranging from 4 to 16 μg/mL.
三种新的具有独特 6/5/7/5 核心的桔青霉素衍生物，即二氢桔青霉素 A-C（分别为-），通过热液喷口相关真菌 TW132-59 的发酵分离得到。它们的结构通过核磁共振、质谱和电子圆二色性计算得到明确的确定。二氢桔青霉素 A-C 代表了一种具有十氢-5,9,4-（亚丙基[1,1,3]三基）环辛[4]呋喃环系的新颖笼状碳骨架。二氢桔青霉素 A-C 对 、 、 和 显示出中等的抗真菌活性，对 、 、 和 显示出抗菌活性，最小抑菌浓度范围为 4 至 16 μg/mL。
