Dicitrinols A-C: Citrinin Derivatives from Hydrothermal Vent-Associated Fungus TW132-59.

Three new unusual citrinin derivatives with a unique 6/5/7/5 core, dicitrinols A-C (-, respectively), were isolated via the fermentation of hydrothermal vent-associated fungus TW132-59. Their structures were unambiguously determined by nuclear magnetic resonance, mass spectrometry, and electronic circular dichroism calculations. Dicitrinols A-C represent a novel cage carbon skeleton with a decahydro-5,9,4-(epipropane[1,1,3]triyl)cycloocta[]furan ring system. Dicitrinols A-C showed moderate antifungal activity against , , and and antibacterial activity against , , and with minimum inhibitory concentrations ranging from 4 to 16 μg/mL.