来自内生真菌核盘青霉PSU-A13的氮杂菲酮和异香豆素衍生物。
Azaphilone and isocoumarin derivatives from the endophytic fungus Penicillium sclerotiorum PSU-A13.
作者信息
Arunpanichlert Jiraporn, Rukachaisirikul Vatcharin, Sukpondma Yaowapa, Phongpaichit Souwalak, Tewtrakul Supinya, Rungjindamai Nuttawut, Sakayaroj Jariya
机构信息
Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
出版信息
Chem Pharm Bull (Tokyo). 2010 Aug;58(8):1033-6. doi: 10.1248/cpb.58.1033.
Two new azaphilone derivatives, penicilazaphilones A (1) and B (2), and one new isocoumarin, penicilisorin (3), together with six known compounds were isolated from the endophytic fungus Penicillium sclerotiorum PSU-A13. Their structures were identified by analysis of spectroscopic data. The antimicrobial activity against Staphylococcus aureus, Candida albicans and Cryptococcus neoformans as well as the inhibitory effect on human immunodeficiency virus (HIV)-1 integrase and protease were examined.
从内生真菌核盘青霉PSU-A13中分离得到了两种新的氮杂蒽酮衍生物，盘菌氮杂蒽酮A（1）和B（2），以及一种新的异香豆素，盘菌异香豆素（3），同时还分离得到了六种已知化合物。通过光谱数据分析确定了它们的结构。检测了它们对金黄色葡萄球菌、白色念珠菌和新型隐球菌的抗菌活性以及对人类免疫缺陷病毒（HIV）-1整合酶和蛋白酶的抑制作用。
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