Jiang Meixiang, Long Yuxing, Liu Yiliang, Li Ran, Xu Jingyi, Chi Tongyue, Sun Menglu, Li Miao, Yu Hao, Yu Lu, Han Xiaobo
Shandong Key Laboratory of Psychiatric and Behavioral Medicine, School of Mental Health, Jining Medical University, Jining 272013, Shandong, China; Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Jining Medical University, Jining 272013, Shandong, China.
Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China.
Stem Cell Res. 2024 Dec;81:103570. doi: 10.1016/j.scr.2024.103570. Epub 2024 Sep 30.
We obtained Peripheral blood mononuclear cells (PBMCs) from a peripheral blood sample of a 19-year-old male schizophrenia patient and successfully established induced pluripotent stem cell (iPSC) line using non-integrated reprogramming technology. This cell line possesses the correct karyotype, shape of an embryonic stem cell, the ability to express particular pluripotency markers, and the capacity to differentiate into three germ layers in vitro. This cell line will serve as an in vitro model for upcoming studies on the etiology of schizophrenia and the creation of novel treatment.
我们从一名19岁男性精神分裂症患者的外周血样本中获取了外周血单个核细胞（PBMCs），并使用非整合重编程技术成功建立了诱导多能干细胞（iPSC）系。该细胞系具有正确的核型、胚胎干细胞形态、表达特定多能性标志物的能力以及在体外分化为三个胚层的能力。该细胞系将作为未来精神分裂症病因学研究和新型治疗方法创建的体外模型。
