阿尔茨海默病和轻度认知障碍的孟德尔随机化：海马体积关联。
Mendelian randomization in Alzheimer's disease and mild cognitive impairment: Hippocampal volume associations.
机构信息
Department of Radiology, Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine, Lianyungang 222004, PR China.
Department of Radiology, The Fourth People's Hospital of Lianyungang, Affiliated Hospital of Nanjing Medical University Kangda, Lianyungang 222000, PR China.
出版信息
Neuroscience. 2024 Nov 22;561:30-42. doi: 10.1016/j.neuroscience.2024.10.007. Epub 2024 Oct 4.
This study investigates the association between cognitive dysfunction and hippocampal volumes in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) using Mendelian randomization. A meta-analysis of 503 healthy controls, 562 MCI patients, and 389 CE patients revealed significant reductions in hippocampal and subregion volumes in MCI and AD compared to controls. While various subregions showed volume reductions, no causal relationship between hippocampal volume and AD was established through Mendelian randomization analysis. In conclusion, significant volume reductions were observed in MCI and AD patients, highlighting the complexity of the relationship between hippocampal volume and cognitive impairment.
本研究采用孟德尔随机化方法探讨了认知功能障碍与阿尔茨海默病（AD）和轻度认知障碍（MCI）中海马体积之间的关联。对 503 名健康对照者、562 名 MCI 患者和 389 名 CE 患者的荟萃分析显示，与对照组相比，MCI 和 AD 患者的海马体和亚区体积明显减少。虽然各个亚区都显示出体积减少，但通过孟德尔随机化分析并未确定海马体体积与 AD 之间存在因果关系。总之，MCI 和 AD 患者的海马体体积显著减少，突出了海马体体积与认知障碍之间关系的复杂性。
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