Universidade Federal de Juiz de Fora, Department of Pharmaceutical Sciences, Juiz de Fora 36038330, Minas Gerais, Brazil; University of Pisa, Department of Pharmacy, Pisa 56122, Toscana, Italy.
Universidade Federal de Juiz de Fora, Department of Pharmaceutical Sciences, Juiz de Fora 36038330, Minas Gerais, Brazil.
Int J Pharm. 2024 Dec 5;666:124804. doi: 10.1016/j.ijpharm.2024.124804. Epub 2024 Oct 4.
Androgenetic alopecia (AGA) is the most common hair loss disorder, affecting millions of men and women worldwide. Current formulations used to treat this condition often lead to a wide variety of side effects, ranging from allergies to sexual disfunction, especially when those drugs are administered orally. In this study, we developed and tested unique formulations containing nanostructured lipid carriers (NLC) composed of lipids extracted from fruit seeds, carrying finasteride to enhance efficacy of AGA treatment. By stabilizing the hydrophobic compounds in the solid matrix, three formulations of NLC were engineered and successfully prepared. Further an in vivo model of AGA was induced in rats by the administration of testosterone, as a platform to evaluate the efficiency of the formulations. The chosen formulation exhibited high bioavailability, medium size of 124.5 nm and PdI of 0.143, without systemic absorption. In addition, it promoted efficient and significant follicle restoration in AGA induced rats by increasing number of active bulbs and showed to be a safe formulation for topical application. The results of this research indicate that the presented formulation has significant potential to yield improved outcomes in AGA treatment.
雄激素性脱发（AGA）是最常见的脱发疾病，影响着全球数以百万计的男性和女性。目前用于治疗这种疾病的制剂常常导致各种各样的副作用，从过敏到性功能障碍，尤其是当这些药物口服给药时。在这项研究中，我们开发并测试了含有纳米结构脂质载体（NLC）的独特制剂，这些载体由水果种子中提取的脂质组成，携带非那雄胺以增强 AGA 治疗的效果。通过稳定固体基质中的疏水性化合物，我们设计并成功制备了三种 NLC 制剂。进一步通过给予大鼠睾丸酮来诱导 AGA 的体内模型，作为评估制剂效率的平台。所选制剂表现出高生物利用度、中等大小（124.5nm）和 PdI（0.143），没有全身吸收。此外，它通过增加活跃的毛囊数量促进 AGA 诱导的大鼠毛囊的有效和显著恢复，并且表现出作为局部应用的安全制剂。这项研究的结果表明，所提出的制剂在 AGA 治疗方面具有显著的潜力，可以产生更好的效果。
