Kahramanmaraş Sütçü İmam University Faculty of Medicine, Department of Dermatology, Kahramanmaraş, 46100, Turkey.
Kahramanmaraş Sütçü İmam University School of Medicine, Department of Biochemistry, Kahramanmaras, 46100, Turkey.
Arch Dermatol Res. 2024 Oct 5;316(9):658. doi: 10.1007/s00403-024-03380-8.
There are studies revealing the effects of estrogen receptors alpha (α) and beta (β) on hair follicles. However, the effects of G protein-coupled estrogen receptors (GPER-1) on hair follicles have not been elucidated. This study aims to evaluate the relationship between serum GPER-1 levels and the severity and duration of the disease in patients with androgenetic alopecia (AGA). The study included 81 patients with AGA aged 18 to 50 years (22 men and 19 women with an onset of AGA more than 5 years, and 20 men and 20 women with an onset of AGA less than 5 years) and 40 healthy controls (20 men, 20 women). The mean age of participants with AGA was 29.12 ± 8.15 (18-50), and the mean age of the control group was 25.21± 4.71 (19-42). Serum GPER-1 levels were measured, and the relationship between GPER-1 levels and duration of the disease, severity of the disease, and sex was statistically evaluated. The serum level of GPER-1 was significantly higher in patients with AGA as compared to the control group (p < 0.001). A negative correlation was found between serum GPER-1 levels and the duration of the disease in both men and women (p < 0.001, r = 0.793; p < 0.001, r = 0.711, respectively). There was a significant relationship between serum GPER-1 levels and the severity of the disease in both men and women (p = 0.003; p = 0.002, respectively). Additionally, a significant difference in GPER-1 levels was noted between male and female patients with AGA (p = 0.001). However, no statistically significant relationship was identified between GPER-1 levels and estrogen levels (p = 0.097). The higher levels of GPER-1 in patients with AGA compared to the control group, and the significant relationship between GPER-1 levels and both the duration and severity of the disease, suggest an estrogen-independent role of GPER-1 in the pathogenesis of AGA. The fact that GPER-1 levels are high in the early stages of AGA when inflammation is prominent suggests that treatments targeting these receptors may be effective at this stage.
有研究揭示了雌激素受体 α（α）和β（β）对毛囊的影响。然而，G 蛋白偶联雌激素受体（GPER-1）对毛囊的影响尚未阐明。本研究旨在评估血清 GPER-1 水平与雄激素性脱发（AGA）患者疾病严重程度和病程的关系。研究纳入了 81 例 18 至 50 岁的 AGA 患者（22 名男性和 19 名女性，AGA 发病时间超过 5 年；20 名男性和 20 名女性，AGA 发病时间少于 5 年）和 40 名健康对照者（20 名男性，20 名女性）。AGA 患者的平均年龄为 29.12±8.15 岁（18-50 岁），对照组的平均年龄为 25.21±4.71 岁（19-42 岁）。测量了血清 GPER-1 水平，并对 GPER-1 水平与病程、疾病严重程度和性别之间的关系进行了统计学评估。与对照组相比，AGA 患者的血清 GPER-1 水平显著升高（p<0.001）。在男性和女性中，血清 GPER-1 水平与病程呈负相关（p<0.001，r=0.793；p<0.001，r=0.711）。在男性和女性中，血清 GPER-1 水平与疾病严重程度均呈显著相关（p=0.003；p=0.002）。此外，AGA 男性和女性患者的 GPER-1 水平存在显著差异（p=0.001）。然而，GPER-1 水平与雌激素水平之间无统计学显著关系（p=0.097）。与对照组相比，AGA 患者的血清 GPER-1 水平更高，并且 GPER-1 水平与病程和疾病严重程度均显著相关，提示 GPER-1 在 AGA 的发病机制中发挥了雌激素非依赖性作用。在炎症明显的 AGA 早期阶段 GPER-1 水平较高这一事实表明，针对这些受体的治疗可能在此阶段有效。
