Department of Medical Biochemistry, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Turkey.
Department of Dermatology, University of Health Sciences Gülhane Training and Investigation Hospital, Ankara, Turkey.
J Cosmet Dermatol. 2021 Jun;20(6):1855-1859. doi: 10.1111/jocd.13732. Epub 2020 Oct 7.
Androgenetic alopecia (AGA) is the most common type of hair loss and affects approximately 50% of the male population.
In the present study, to investigate microinflammation, perifollicular fibrosis, and oxidative stress in AGA cases, some serum biomarker levels were measured and evaluated.
PATIENTS/METHODS: Serum samples were drawn from patients (n = 58) and control (n = 30) groups referring to Atatürk Training and Investigation Hospital Dermatology Outpatient clinic. In serum samples, NF-κB, TNF-α, TGF-β1, thioredoxin, nitric oxide, TOS, TAS, and thiol disulfide homeostasis (native thiol, total thiol, disulfide) were measured and evaluated.
In patients with AGA, NF-κB (P = .005), TNF-α (P = .008), TGF-β1 (P = .028), thioredoxin (P = .004), nitric oxide (P < .001), and TOS (P < .001) serum levels were found to be significantly higher than those in control group, while TAS (P = .003), native thiol (P < .001), total thiol (P < .001), and disulfide (P < .001) serum levels were found to be significantly lower.
According to the results of the present study, it was concluded that in that AGA androgens lead to oxidative stress by increasing free oxygen radicals, which accelerates hair loss by causing microinflammation and fibrosis. The recognition of the effect of androgens and associated factors on the hair follicle cycle is essential for the development of new and effective treatment methods.
雄激素性脱发（AGA）是最常见的脱发类型，影响大约 50%的男性人群。
本研究旨在探讨 AGA 病例中的微炎症、毛囊周围纤维化和氧化应激，测量并评估了一些血清生物标志物水平。
患者/方法：从 Atatürk 培训和研究医院皮肤科门诊就诊的患者（n=58）和对照组（n=30）中抽取血清样本。在血清样本中，测量并评估了 NF-κB、TNF-α、TGF-β1、硫氧还蛋白、一氧化氮、TOS、TAS 和硫醇二硫化物稳态（天然硫醇、总硫醇、二硫化物）。
AGA 患者的 NF-κB（P=0.005）、TNF-α（P=0.008）、TGF-β1（P=0.028）、硫氧还蛋白（P=0.004）、一氧化氮（P<0.001）和 TOS（P<0.001）血清水平明显高于对照组，而 TAS（P=0.003）、天然硫醇（P<0.001）、总硫醇（P<0.001）和二硫化物（P<0.001）血清水平明显低于对照组。
根据本研究结果，AGA 中雄激素通过增加自由基而导致氧化应激，通过引起微炎症和纤维化加速脱发。认识雄激素及其相关因素对毛囊周期的影响对于开发新的有效治疗方法至关重要。
