School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, LE11 3TU, UK.
Exercise and Sports Science Programme, School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, 16150, Malaysia.
Metabolomics. 2024 Oct 5;20(5):110. doi: 10.1007/s11306-024-02177-0.
Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with poor cardiovascular health. Exercise is a known cardioprotective activity but the impact of an acute bout of exercise on TMAO production is unknown.
OBJECTIVES/METHODS: This study assessed choline-derived production of TMAO following a single bout of intermittent exercise in a young, healthy cohort.
Choline supplemented after either exercise or a time-matched resting period demonstrated a similar increase in circulating TMAO across an 8-hour period.
This suggests that a single bout of intermittent exercise does not alter gut microbial metabolic behaviour and thus does not provide additional cardioprotective benefits related to blood levels of TMAO.
三甲基胺 N-氧化物（TMAO）是一种与心血管健康状况不佳有关的肠道细菌依赖性代谢物。运动是一种已知的心脏保护活动，但单次运动对 TMAO 产生的影响尚不清楚。
目的/方法：本研究评估了年轻健康人群单次间歇性运动后 TMAO 胆碱衍生的产生情况。
补充胆碱无论是在运动后还是在时间匹配的休息期间，都能在 8 小时内使循环 TMAO 水平相似地增加。
这表明单次间歇性运动不会改变肠道微生物的代谢行为，因此不会提供与 TMAO 血水平相关的额外心脏保护益处。
