Collier R J, Haynes N B, Kiser T E, Hafs H D
J Anim Sci. 1979 Dec;49(6):1517-21. doi: 10.2527/jas1979.4961517x.
Plasma glucose and serum insulin, growth hormone and glucocorticoid concentrations were determined in five yearling bulls given (im) 5, 15 or 30 mg prostaglandin E2 (PGE2), 30 mg prostaglandin F2 alpha(PGF2 alpha) or saline. Jugular blood was collected at frequent intervals around the time of injection and at .5--hr intervals from 1 to 9 hr after injections. Thirty milligrams PGE2 and 30 mg PGF2 alpha each caused 15- to 20-fold increases in serum glucocorticoids. Glucocorticoids increased with increasing doses of PGE2. Although PGE2 and PGF2 alpha each increased blood growth hormone, this effect was about twofold larger after PGE2. By contrast, PGE2 depressed serum insulin about 50% for 1 hr, then insulin increased about sixfold until 3 to 4 hours. Blood serum insulin increased after PGF2 alpha, but this effect only approached significance (P less than .10). Plasma glucose increased about 10 mg/100 ml after PGE2, but was not affected significantly by PGF2 alpha. Thus, the effects of PGE2 and PGF2 alpha on hormones which control glucose metabolism differ markedly. We speculate that PGE2 caused a twofold increase in growth hormone secretion within 10 to 20 min, that increased growth hormone induced increased blood glucose within 1 to 2 hr and that increased glucose caused increased insulin secretion at 2 to 4 hr, but we cannot rule out a transitory (1 hr) suppressive effect of PGE2 directly on the pancreas.
对5头一岁公牛进行如下处理：分别静脉注射5毫克、15毫克或30毫克前列腺素E2（PGE2）、30毫克前列腺素F2α（PGF2α）或生理盐水，然后测定其血浆葡萄糖、血清胰岛素、生长激素和糖皮质激素的浓度。在注射前后的一段时间内频繁采集颈静脉血，并在注射后1至9小时每隔0.5小时采集一次。30毫克PGE2和30毫克PGF2α均可使血清糖皮质激素增加15至20倍。糖皮质激素随着PGE2剂量的增加而升高。虽然PGE2和PGF2α均可使血液生长激素升高，但PGE2的这种作用约为PGF2α的两倍。相比之下，PGE2可使血清胰岛素在1小时内降低约50%，然后胰岛素在3至4小时内升高约6倍。PGF2α可使血清胰岛素升高，但这种作用仅接近显著水平（P<0.10）。PGE2可使血浆葡萄糖升高约10毫克/100毫升，但PGF2α对其无显著影响。因此，PGE2和PGF2α对控制葡萄糖代谢的激素的作用明显不同。我们推测，PGE2在10至20分钟内使生长激素分泌增加两倍，1至2小时内升高的生长激素导致血糖升高，2至4小时内升高的血糖导致胰岛素分泌增加，但我们不能排除PGE2直接对胰腺产生的短暂（1小时）抑制作用。
