State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, 100190, China; School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China.
State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, 100190, China; School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China.
Biosens Bioelectron. 2025 Jan 1;267:116837. doi: 10.1016/j.bios.2024.116837. Epub 2024 Oct 4.
Microelectrode arrays (MEAs) are pivotal brain-machine interface devices that facilitate in situ and real-time detection of neurophysiological signals and neurotransmitter data within the brain. These capabilities are essential for understanding neural system functions, treating brain disorders, and developing advanced brain-machine interfaces. To enhance the performance of MEAs, this study developed a crosslinked hydrogel coating of calcium alginate (CA) and chitosan (CS) loaded with the anti-inflammatory drug dexamethasone sodium phosphate (DSP). By modifying the MEAs with this hydrogel and various conductive nanomaterials, including platinum nanoparticles (PtNPs) and poly (3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT: PSS), the electrical properties and biocompatibility of the electrodes were optimized. The hydrogel coating matches the mechanical properties of brain tissue more effectively and, by actively releasing anti-inflammatory drugs, significantly reduces post-implantation tissue inflammation, extends the electrodes' lifespan, and enhances the quality of neural activity detection. Additionally, this modification ensures high sensitivity and specificity in the detection of dopamine (DA), displaying high-quality dual-mode neural activity during in vivo testing and revealing significant functional differences between neuron types under various physiological states (anesthetized and awake). Overall, this study showcases the significant application value of bioactive hydrogels as excellent nanobiointerfaces and drug delivery carriers for long-term neural monitoring. This approach has the potential to enhance the functionality and acceptance of brain-machine interface devices in medical practice and has profound implications for future neuroscience research and the development of strategies for treating neurological diseases.
微电极阵列（MEA）是一种重要的脑机接口设备，可实现脑内神经生理信号和神经递质数据的原位和实时检测。这些能力对于理解神经系统功能、治疗脑部疾病和开发先进的脑机接口至关重要。为了提高 MEA 的性能，本研究开发了一种交联的海藻酸钠（CA）和壳聚糖（CS）水凝胶，其中负载了抗炎药物磷酸地塞米松钠（DSP）。通过将这种水凝胶和各种导电纳米材料（包括铂纳米颗粒（PtNPs）和聚（3,4-亚乙基二氧噻吩）聚苯乙烯磺酸盐（PEDOT：PSS））修饰 MEA，可以优化电极的电学性能和生物相容性。水凝胶涂层更有效地匹配脑组织的机械性能，并且通过主动释放抗炎药物，显著降低了植入后的组织炎症，延长了电极的寿命，并提高了神经活动检测的质量。此外，这种修饰确保了多巴胺（DA）检测的高灵敏度和特异性，在体内测试中显示出高质量的双模态神经活动，并揭示了各种生理状态（麻醉和清醒）下神经元类型之间的显著功能差异。总的来说，本研究展示了生物活性水凝胶作为优异的纳米生物界面和药物输送载体在长期神经监测中的重要应用价值。这种方法有可能增强脑机接口设备在医学实践中的功能和接受度，对未来的神经科学研究和治疗神经疾病策略的发展具有深远的意义。
