Diabetes Research Centre, College of Life Sciences, University of Leicester, UK and NIHR Leicester Biomedical Research Centre, UK.
Diabetes Research Centre, College of Life Sciences, University of Leicester, UK and NIHR Leicester Biomedical Research Centre, UK; Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, UK.
Diabetes Res Clin Pract. 2024 Nov;217:111886. doi: 10.1016/j.diabres.2024.111886. Epub 2024 Oct 5.
To examine the associations of substituting sedentary behaviour (SB) for sleep, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) with physical function and wellbeing.
Cross-sectional data from 808 adults with Type 2 Diabetes Mellitus, (T2DM) were included. 24-hour behaviours were ascertained through accelerometery. Isotemporal substitution was used to estimate the theoretical substitution of SB for other 24-hour behaviours on associations with physical function and wellbeing markers.
Reallocating 30 min of SB to sleep was beneficially associated with 1.0% (95% CI: 0.1-1.9) higher sit-to-stand-60 (STS60) and 1.2% (0.1-2.3) Duke Activity Status Index (DASI) scores, 3.6% (1.5-5.5) lower Patient Hospital Questionnaire-9 (PHQ9) and 1.9% lower (0.1-3.7) Diabetes Distress scores. Whilst substituting SB with MVPA was associated with 3.8% (2.2-5.4) higher STS60 and 3.9% (2.0-5.9) DASI scores, and 4.7% (0.3-9.0) lower PHQ9 score. Replacing SB with LPA was associated with 4.1% (1.0-7.1) lower PHQ9 score.
In adults with T2DM, theoretically replacing SB with sleep and physical activity, particularly MVPA is beneficially associated with markers of physical function and wellbeing. For wellbeing, associations for sleep were comparable (depression), or greater (diabetes distress), than for MVPA.
研究用久坐行为（SB）替代睡眠、轻度体力活动（LPA）或中高强度体力活动（MVPA）与身体功能和健康相关的关联。
本研究纳入了 808 名 2 型糖尿病患者的横断面数据。通过加速度计确定 24 小时行为。等时替代法用于估计 SB 替代其他 24 小时行为对身体功能和健康指标的关联的理论替代情况。
将 30 分钟的 SB 重新分配到睡眠中与坐立-站立 60 次（STS60）提高 1.0%（95%CI：0.1-1.9）和杜克活动状态指数（DASI）评分提高 1.2%（0.1-2.3）、患者医院问卷-9 （PHQ9）评分降低 3.6%（1.5-5.5）和糖尿病困扰评分降低 1.9%（0.1-3.7）有关。而用 MVPA 替代 SB 与 STS60 提高 3.8%（2.2-5.4）和 DASI 评分提高 3.9%（2.0-5.9）以及 PHQ9 评分降低 4.7%（0.3-9.0）有关。用 LPA 替代 SB 与 PHQ9 评分降低 4.1%（1.0-7.1）有关。
在 2 型糖尿病患者中，从理论上用睡眠和体力活动替代 SB，特别是 MVPA 与身体功能和健康指标呈正相关。对于健康相关的指标，睡眠的关联（抑郁）与 MVPA 相当，或更大（糖尿病困扰）。
